Mi Pengbing, Liao Peiqiu, Tu Tao, Bi Xihe
Department of Chemistry, Northeast Normal University, Changchun 130024 (P. R. China) http://www.bigroup.com.cn/
Chemistry. 2015 Mar 27;21(14):5332-6. doi: 10.1002/chem.201406227. Epub 2015 Feb 16.
Decarbonylation of saccharins by nickel catalysis enables two kinds of CC bond-forming reactions; homocoupling of saccharins to form biaryls and cycloaddition with alkynes to form benzosultams. The former represents the first reported nickel-catalyzed decarbonylative CC homocoupling reaction, whereas the latter constitutes a powerful method to pharmaceutically relevant benzosultams. The reactions proceed with good functional-group tolerance and excellent regioselectivity.
通过镍催化实现糖精的脱羰基反应可引发两种碳-碳键形成反应；糖精的均偶联反应形成联芳基，以及与炔烃发生环加成反应形成苯并磺内酰胺。前者代表了首次报道的镍催化脱羰基碳-碳均偶联反应，而后者则构成了一种合成药学相关苯并磺内酰胺的有效方法。这些反应具有良好的官能团耐受性和出色的区域选择性。
