de Castro e Silva E J, Antunes-Rodrigues J
Departamento de Fisiologia, Instituto de Ciências da Saúde, Universidad Federal da Bahia, Salvador, Brasil.
Horm Metab Res. 1989 Apr;21(4):179-81. doi: 10.1055/s-2007-1009185.
The influence of the central adrenergic system on basal prolactin secretion was investigated in the rat. Several selective adrenoceptor blockers were centrally administered and their effects on prolactin secretion were observed. Blockade of beta-1 receptors by practolol, beta-2 receptors by IPS 339 and alpha-2 receptors by DG-5128 did not modify basal prolactin secretion, but alpha-1 adrenoceptor blockade by prazosin strongly enhanced prolactin plasma levels. These findings suggest that noradrenergic pathways in the central nervous system exert inhibitory tone on basal prolactin secretion, and that this effect seems to be mediated by alpha-1 adrenoceptors.
在大鼠中研究了中枢肾上腺素能系统对基础催乳素分泌的影响。几种选择性肾上腺素能受体阻滞剂经中枢给药，并观察它们对催乳素分泌的影响。心得宁对β-1受体的阻断、IPS 339对β-2受体的阻断以及DG-5128对α-2受体的阻断均未改变基础催乳素分泌，但哌唑嗪对α-1肾上腺素能受体的阻断强烈提高了催乳素的血浆水平。这些发现表明，中枢神经系统中的去甲肾上腺素能通路对基础催乳素分泌发挥抑制作用，且这种作用似乎由α-1肾上腺素能受体介导。
