心肌营养素-1与动脉僵硬度增加的风险相关。

Cardiotrophin-1 is associated with increased risk of arterial stiffness.

作者信息

Hung Hao-Chang, Lu Feng-Hwa, Ou Horng-Yih, Wu Hung-Tsung, Wu Jin-Shang, Yang Yi-Ching, Chang Chih-Jen

机构信息

Division of Endocrinology & Metabolism, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.

出版信息

Biomark Med. 2015;9(2):123-30. doi: 10.2217/bmm.14.87.

DOI:10.2217/bmm.14.87

PMID:25689900

Abstract

AIM

Cardiotrophin-1 null mice presented decreased arterial stiffness. The aim of this study is to investigate the relationship between cardiotrophin-1 and arterial stiffness, assessed by brachial-ankle pulse-wave velocity (baPWV).

METHODS

We enrolled 300 subjects, 200 with baPWV >1400 and 100 with baPWV ≤1400 cm/s.

RESULTS

Cardiotrophin-1 levels were significantly higher in subjects with baPWV >1400 than those with baPWV ≤1400 cm/s. The multivariate logistic regression analysis showed that age, prehypertension, hypertension and cardiotrophin-1 were independently associated with baPWV >1400 cm/s after adjusting for gender, obesity, diabetes, homeostasis model assessment-insulin resistance, total cholesterol, high-density lipoprotein cholesterol, triglyceride, high-sensitivity C-reactive protein, creatinine, smoking and habitual exercise.

CONCLUSION

Cardiotrophin-1 is positively related to baPWV independent of traditional cardiometabolic risk factors for arterial stiffness.

摘要

目的

心肌营养素-1基因敲除小鼠的动脉僵硬度降低。本研究旨在探讨通过臂踝脉搏波速度（baPWV）评估的心肌营养素-1与动脉僵硬度之间的关系。

方法

我们招募了300名受试者，其中200名baPWV>1400，100名baPWV≤1400 cm/s。

结果

baPWV>1400的受试者心肌营养素-1水平显著高于baPWV≤1400 cm/s的受试者。多因素逻辑回归分析显示，在调整性别、肥胖、糖尿病、稳态模型评估-胰岛素抵抗、总胆固醇、高密度脂蛋白胆固醇、甘油三酯、高敏C反应蛋白、肌酐、吸烟和习惯性运动后，年龄、高血压前期、高血压和心肌营养素-1与baPWV>1400 cm/s独立相关。