Division of Endocrinology, Department of Internal Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, 211, Eonju-ro, Gangnam-gu, Seoul, South Korea.
Severance Institute for Vascular and Metabolic Research, Yonsei University College of Medicine, Seoul, South Korea.
Cardiovasc Diabetol. 2018 Mar 21;17(1):41. doi: 10.1186/s12933-018-0692-1.
The triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between the TyG index and arterial stiffness in adults. Therefore, we evaluated the relationship between the TyG index and arterial stiffness as measured based on brachial ankle pulse wave velocity (baPWV) in Korean adults.
A total of 3587 subjects were enrolled in this study. Anthropometric and cardiovascular risk factors were measured. The TyG index was calculated as ln[fasting triglycerides(mg/dl) × fasting glucose(mg/dl)/2], and the insulin resistance index of homeostasis model assessment (HOMA-IR) was estimated. Arterial stiffness was determined by measuring baPWV.
The subjects were stratified into four groups based on the TyG index. There were significant differences in cardiovascular parameters among the groups; the mean baPWV increased significantly with increasing TyG index. According to the logistic regression analysis after adjusting for multiple risk factors, the odds ratio (95% CI) for increased baPWV (> 75th percentile) for the highest and lowest quartiles of the TyG index was 2.92 (1.92-4.44) in men and 1.84 (1.15-2.96) in women, and the odds ratio for increased baPWV for the highest and lowest quartiles of the HOMA-IR was 1.80 (1.17-2.78) in men and 1.46 (1.06-2.47) in women, respectively.
The TyG index is more independently associated with increased arterial stiffness than HOMA-IR in Korean adults.
三酰甘油葡萄糖（TyG）指数已被认为是胰岛素抵抗的一种简单替代标志物。然而，关于 TyG 指数与成年人动脉僵硬之间的关联的数据有限。因此，我们评估了 TyG 指数与基于肱踝脉搏波速度（baPWV）的韩国成年人动脉僵硬之间的关系。
本研究共纳入 3587 名受试者。测量了人体测量和心血管危险因素。TyG 指数的计算方法为 ln[空腹三酰甘油（mg/dl）×空腹血糖（mg/dl）/2]，并估计了稳态模型评估的胰岛素抵抗指数（HOMA-IR）。通过测量 baPWV 来确定动脉僵硬。
根据 TyG 指数将受试者分为四组。各组之间心血管参数存在显著差异；平均 baPWV 随 TyG 指数的增加而显著升高。经多因素调整后的逻辑回归分析显示，TyG 指数最高和最低四分位数组的 baPWV 升高（>第 75 百分位数）的比值比（95%CI）分别为男性 2.92（1.92-4.44）和女性 1.84（1.15-2.96），HOMA-IR 最高和最低四分位数组的 baPWV 升高的比值比分别为男性 1.80（1.17-2.78）和女性 1.46（1.06-2.47）。
在韩国成年人中，TyG 指数与动脉僵硬的相关性比 HOMA-IR 更独立。
