从链霉菌 RM-7-15 中分离得到的 ansamycin 类似物 Herbimycins D-F。
Herbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15.
机构信息
Center for Pharmaceutical Research and Innovation, College of Pharmacy, University of Kentucky , 789 South Limestone Street, Lexington, Kentucky 40536-0596, United States.
出版信息
J Nat Prod. 2013 Sep 27;76(9):1619-26. doi: 10.1021/np400308w. Epub 2013 Aug 15.
Abstract
Bacterial strains belonging to the class actinomycetes were isolated from the soil near a thermal vent of the Ruth Mullins coal fire (Appalachian Mountains of eastern Kentucky). High-resolution electrospray ionization mass spectrometry and ultraviolet absorption profiles of metabolites from one of the isolates (Streptomyces sp. RM-7-15) revealed the presence of a unique set of metabolites ultimately determined to be herbimycins D-F (1-3). In addition, herbimycin A (4), dihydroherbimycin A (TAN 420E) (7), and the structurally distinct antibiotic bicycylomycin were isolated from the crude extract of Streptomyces sp. RM-7-15. Herbimycins A and D-F (1-3) displayed comparable binding affinities to the Hsp90α. While the new analogues were found to be inactive in cancer cell cytotoxicity and antimicrobial assays, they may offer new insights in the context of nontoxic ansamycin-based Hsp90 inhibitors for the treatment of neurodegenerative disease.
摘要
从位于肯塔基州东部阿巴拉契亚山脉 Ruth Mullins 煤火附近热液喷口的土壤中分离到放线菌纲的细菌菌株。一种分离物（链霉菌属 RM-7-15）的高分辨率电喷雾电离质谱和代谢物的紫外吸收图谱显示存在一组独特的代谢物，最终确定为 herbimycins D-F（1-3）。此外，从链霉菌属 RM-7-15 的粗提物中分离得到 herbimycin A（4）、二氢 herbimycin A（TAN 420E）（7）和结构独特的抗生素双环霉素。Herbimycins A 和 D-F（1-3）与 Hsp90α 具有相当的结合亲和力。虽然新类似物在癌细胞细胞毒性和抗菌测定中被发现没有活性，但它们可能为基于非毒性 ansamycin 的 Hsp90 抑制剂治疗神经退行性疾病提供新的见解。
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