Podtaev S, Nikolaev D, Samartsev V, Gavrilov V, Tsiberkin K
Institute of Continuous Media Mechanics, Korolyov str.1, Perm 614013, Russia.
Physiol Meas. 2015 Mar;36(3):561-77. doi: 10.1088/0967-3334/36/3/561. Epub 2015 Feb 18.
A study of the α- and β-dispersion of skin bioimpedance dependence on temperature and micro-hemodynamics is presented. The vascular tone changes during the cold test are verified by the wavelet-analysis of skin temperature signals obtained simultaneously with impedance measurements. Thirty three normal healthy subjects of 28 ± 7 years old were entered into the study. The tetra-polar electrode system was used to record the resistance and reactance; measurements were carried out at 67 frequencies, in a frequency range from 2 Hz to 50 kHz. It has been found that the impedance decreases with vasodilation and increases with vasoconstriction. The high values of correlation among thermal oscillation amplitudes and Nyquist diagram parameters prove the impedance dependence on blood flow in three frequency bands corresponding to the myogenic, neurogenic and endothelial vascular tone regulation mechanisms. Using an equivalent RC circuit, we obtained the changes in the Nyquist diagram matching the experimental data. The proposed descriptive α-dispersion model can be used to study mechanisms responsible for intercellular interaction.
本文介绍了一项关于皮肤生物阻抗的α和β色散对温度及微循环动力学依赖性的研究。通过对与阻抗测量同时获得的皮肤温度信号进行小波分析，验证了冷试验期间血管张力的变化。33名年龄在28±7岁的正常健康受试者参与了该研究。采用四极电极系统记录电阻和电抗；在2Hz至50kHz的频率范围内，于67个频率点进行测量。研究发现，阻抗随血管舒张而降低，随血管收缩而增加。热振荡幅度与奈奎斯特图参数之间的高相关性证明了在对应于肌源性、神经源性和内皮血管张力调节机制的三个频带中，阻抗对血流的依赖性。利用等效RC电路，我们获得了与实验数据相匹配的奈奎斯特图变化。所提出的描述性α色散模型可用于研究细胞间相互作用的机制。
