Montero Hilda, García-Román Rebeca, Mora Silvia I
Public Health Institute, University of Veracruz, Veracruz 91190, Mexico.
Preparative Procedures and Access to Proteomic Services Unit, Institute of Biomedical Research, National Autonomous University of Mexico. Distrito Federal 04510, Mexico.
Viruses. 2015 Feb 16;7(2):739-50. doi: 10.3390/v7020739.
Translation is a complex process involving diverse cellular proteins, including the translation initiation factor eIF4E, which has been shown to be a protein that is a point for translational regulation. Viruses require components from the host cell to complete their replication cycles. Various studies show how eIF4E and its regulatory cellular proteins are manipulated during viral infections. Interestingly, viral action mechanisms in eIF4E are diverse and have an impact not only on viral protein synthesis, but also on other aspects that are important for the replication cycle, such as the proliferation of infected cells and stimulation of viral reactivation. This review shows how some viruses use eIF4E and its regulatory proteins for their own benefit in order to spread themselves.
翻译是一个复杂的过程，涉及多种细胞蛋白，包括翻译起始因子eIF4E，该因子已被证明是一个翻译调控点。病毒需要宿主细胞的成分来完成其复制周期。各种研究表明，在病毒感染期间，eIF4E及其调节性细胞蛋白是如何被操控的。有趣的是，eIF4E中的病毒作用机制多种多样，不仅对病毒蛋白合成有影响，而且对复制周期的其他重要方面也有影响，如受感染细胞的增殖和病毒再激活的刺激。这篇综述展示了一些病毒如何利用eIF4E及其调节蛋白来为自身利益服务，以便传播它们自己。
