Shinoda H, Marini A M, Cosi C, Schwartz J P
Clinical Neuroscience Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Science. 1989 Jul 28;245(4916):415-7. doi: 10.1126/science.2569236.
Astrocytes have many neuronal characteristics, such as neurotransmitter receptors, ion channels, and neurotransmitter uptake systems. Cultured astrocytes were shown to express certain neuropeptide genes, with specificity for both the gene expressed and the brain region from which the cells were prepared. Somatostatin messenger RNA and peptides were detected only in cerebellar astrocytes, whereas proenkephalin messenger RNA and enkephalin peptides were present in astrocytes of cortex, cerebellum, and striatum. Cholecystokinin was not expressed in any of the cells. These results support the hypothesis that peptides synthesized in astrocytes may play a role in the development of the central nervous system.
星形胶质细胞具有许多神经元特征，如神经递质受体、离子通道和神经递质摄取系统。培养的星形胶质细胞被证明可表达某些神经肽基因，对所表达的基因以及制备细胞的脑区均具有特异性。仅在小脑星形胶质细胞中检测到生长抑素信使核糖核酸和肽，而前脑啡肽信使核糖核酸和脑啡肽肽则存在于皮质、小脑和纹状体的星形胶质细胞中。胆囊收缩素在任何细胞中均未表达。这些结果支持了星形胶质细胞中合成的肽可能在中枢神经系统发育中起作用这一假说。
