Wu Ying, He Ji C, Zhou Xing T, Chu Ren Y
Eye & ENT Hospital of Fudan University, Shanghai, China.
New England College of Optometry, Boston, Massachusetts, United States of America.
PLoS One. 2015 Feb 18;10(2):e0117256. doi: 10.1371/journal.pone.0117256. eCollection 2015.
To explore the relationship between ablation parameters of myopic laser surgery and measurement area of wavefront aberration (WA) with Hartmann-Shack wavefront sensor.
58 subjects undergone myopic laser surgeries and 74 uncorrected myopic subjects were enrolled in this experiment. The laser ablation parameters were obtained from surgical records, which included spherical error (Rx), depth, and optical zone (OZ) of ablation. The measured area of WA was tested by the WASCA, and the real pupil size was tested by Pentacam. The corneal eccentricity (E value) and curvature was also measured with the Pentacam. All the measurements were performed under mydriatic condition.
For uncorrected myopic eyes, the measured area of WA was similar with the real pupil size. But for the corrected eyes, the measured area of WA was smaller than the real pupil size with a mean difference of 0.66 ± 0.54 mm for moderate myopia (t = 6.45, p < 0.0001) and 1.76 ± 0.55 mm for high myopia (t = 18.92, p < 0.0001), but not for mild myopia. The Rx (t = -3.20, p = 0.0017), OZ (t = 64.4, p < 0.0001) and postoperative corneal E value (t = 2.52, p = 0.017) were the independent factors of measured area of WA. Measured area of WA = -0.81Rx + 1.13OZ + 0.49*postoperative corneal E value (r2 = 0.997).
The WASCA has a limitation in measuring wavefront aberration over the whole pupil area when it's used for patients received myopic laser surgery. The measured area is smaller than the real pupil size and depends linearly on ablation depth, optical zone and corneal eccentricity.
探讨近视激光手术的消融参数与使用哈特曼-夏克波前传感器测量的波前像差（WA）测量区域之间的关系。
本实验纳入了58例行近视激光手术的受试者和74例未矫正近视的受试者。激光消融参数从手术记录中获取，包括消融的球镜度数（Rx）、深度和光学区（OZ）。WA的测量区域通过WASCA进行检测，真实瞳孔大小通过Pentacam进行检测。角膜偏心度（E值）和曲率也用Pentacam进行测量。所有测量均在散瞳状态下进行。
对于未矫正的近视眼睛，WA的测量区域与真实瞳孔大小相似。但对于矫正后的眼睛，WA的测量区域小于真实瞳孔大小，中度近视的平均差值为0.66±0.54mm（t = 6.45，p < 0.0001），高度近视为1.76±0.55mm（t = 18.92，p < 0.0001），而轻度近视则不然。Rx（t = -3.20，p = 0.0017）、OZ（t = 64.4，p < 0.0001）和术后角膜E值（t = 2.52，p = 0.017）是WA测量区域的独立影响因素。WA测量区域 = -0.81×Rx + 1.13×OZ + 0.49×术后角膜E值（r2 = 0.997）。
当WASCA用于接受近视激光手术的患者时，在测量整个瞳孔区域的波前像差方面存在局限性。测量区域小于真实瞳孔大小，且与消融深度、光学区和角膜偏心度呈线性相关。
