Aydin T, Sofikerim M, Yucel B, Karadag M, Tokat F
a Assisted Reproduction Unit, Acibadem Hospital , Kayseri , Turkey.
b Department of Urology , Acibadem University , Istanbul , Turkey.
J Obstet Gynaecol. 2015;35(8):829-31. doi: 10.3109/01443615.2015.1009879. Epub 2015 Feb 18.
Non-obstructive azoospermia (NOA) is characterised by absence of sperm in the ejaculate. Significant relationship between the pattern of the testis histopathology of NOA and successful sperm retrieval rate is well known. In this study, we assess efficacy of testicular histopathology on sperm retrieval rates and intracytoplasmic sperm injection results after microdissection testicular sperm extraction in cases of non-obstructive azoospermia. It is a retrospective analysis of 111 NOA patients who have histopathological confirmation. According to histopathological findings, the patients were divided into three groups: Sertoli-cell-only syndrome (SCOS), maturation arrest (MA) and hypospermatogenesis. Sperm retrieval rate was significantly higher in hypospermatogenesis group compared with that in SCOS and MA groups. In terms of fertilisation and clinical pregnancy rates, there was no significant difference between the groups. As a result, compared with MA and SCOS, hypospermatogenesis has higher sperm retrieval rates. Our study revealed that once successful sperm retrieval is achieved, fertilisation and clinical pregnancy rates are similar in NOA patients.
非梗阻性无精子症（NOA）的特征是精液中无精子。NOA患者睾丸组织病理学模式与成功取精率之间的显著关系是众所周知的。在本研究中，我们评估了非梗阻性无精子症患者在显微外科睾丸精子提取术后，睾丸组织病理学对取精率和卵胞浆内单精子注射结果的影响。这是一项对111例经组织病理学证实的NOA患者的回顾性分析。根据组织病理学结果，患者被分为三组：唯支持细胞综合征（SCOS）、成熟障碍（MA）和生精低下。生精低下组的取精率显著高于SCOS组和MA组。在受精率和临床妊娠率方面，各组之间无显著差异。因此，与生精障碍和唯支持细胞综合征相比，生精低下的取精率更高。我们的研究表明，一旦成功取精，NOA患者的受精率和临床妊娠率相似。
