人类疱疹病毒6A糖蛋白O的成熟需要糖蛋白H和糖蛋白L的共表达。
Maturation of human herpesvirus 6A glycoprotein O requires coexpression of glycoprotein H and glycoprotein L.
作者信息
Tang Huamin, Mahmoud Nora F, Mori Yasuko
机构信息
Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Japan.
Division of Clinical Virology, Kobe University Graduate School of Medicine, Kobe, Japan Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
出版信息
J Virol. 2015 May;89(9):5159-63. doi: 10.1128/JVI.00140-15. Epub 2015 Feb 18.
Abstract
Glycoprotein O (gO) is conserved among betaherpesviruses, but little is known about the maturation process of gO in human herpesvirus 6 (HHV-6). We found that HHV-6 gO maturation was accompanied by cleavage of its carboxyl terminus and required coexpression of gH and gL, which promoted the export of gO out of the endoplasmic reticulum (ER). Finally, we also found that gO was not required for HHV-6A growth in T cells.
摘要
糖蛋白O（gO）在β疱疹病毒中保守，但对人疱疹病毒6型（HHV-6）中gO的成熟过程知之甚少。我们发现HHV-6 gO的成熟伴随着其羧基末端的切割，并且需要gH和gL的共表达，这促进了gO从内质网（ER）的输出。最后，我们还发现gO对于HHV-6A在T细胞中的生长不是必需的。
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