Zheng Yansong, Li Zongbin, Shu Hua, Liu Minyan, Chen Zhilai, Huang Jianhua
The Chinese PLA General Hospital Health Science Center, FuXing Road 28, Beijing 100853, China.
Institute of Geriatric Cardiology, General Hospital of Chinese PLA, Beijing 100853, China.
Biomed Res Int. 2015;2015:434516. doi: 10.1155/2015/434516. Epub 2015 Jan 28.
The aim of the present study was to analyze the relationship between the sum of the four limbs' pulse pressure (Sum-PP) and brachial-ankle pulse wave velocity (baPWV) and atherosclerosis risk factors and evaluate the feasibility of Sum-PP in diagnosing atherosclerosis systemically. For the purpose, a cross-sectional study was conducted on the basis of medical information of 20748 adults who had a health examination in our hospital. Both Sum-PP and baPWV exhibited significant variations among different human populations grouped by gender, smoking, drinking, and age. Interestingly, Sum-PP had similar varying tendency with baPWV in different populations. And further study in different populations showed that Sum-PP was significantly positively related to baPWV. We also investigated the relationship between Sum-PP, baPWV, and cardiovascular risk factors, respectively. We found that both Sum-PP and baPWV had significant positive correlation with atherosclerosis risk factors while both of them were negatively related to HDL-c. In addition, there was a significant close correlation between Sum-PP and baPWV in the whole population (r = 0.4616, P < 0.0001). Thus, Sum-PP is closely related to baPWV and is of important value for clinical diagnosis of atherosclerosis.
本研究的目的是分析四肢脉压总和（Sum-PP）与臂踝脉搏波速度（baPWV）及动脉粥样硬化危险因素之间的关系，并系统评估Sum-PP在诊断动脉粥样硬化方面的可行性。为此，基于我院20748名进行健康体检的成年人的医学信息开展了一项横断面研究。Sum-PP和baPWV在按性别、吸烟、饮酒和年龄分组的不同人群中均表现出显著差异。有趣的是，Sum-PP在不同人群中与baPWV具有相似的变化趋势。对不同人群的进一步研究表明，Sum-PP与baPWV显著正相关。我们还分别研究了Sum-PP、baPWV与心血管危险因素之间的关系。我们发现，Sum-PP和baPWV均与动脉粥样硬化危险因素显著正相关，而它们与高密度脂蛋白胆固醇（HDL-c）均呈负相关。此外，在整个人群中Sum-PP与baPWV存在显著的密切相关性（r = 0.4616，P < 0.0001）。因此，Sum-PP与baPWV密切相关，对动脉粥样硬化的临床诊断具有重要价值。
