State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
Org Lett. 2015 Mar 6;17(5):1228-31. doi: 10.1021/acs.orglett.5b00193. Epub 2015 Feb 19.
A new Cu(II)-catalyzed oxidative coupling of arenes with malonates has been developed using an amide-oxazoline directing group. The reaction proceeds via C(sp(2))-H activation and malonate coupling, followed by intramolecular oxidative N-C bond formation. A variety of arenes bearing different substituents are shown to be compatible with this reaction.
一种新的酰胺-噁唑啉导向基团促进的铜(II)催化芳基与丙二酸酯的氧化偶联反应已经被开发出来。该反应通过 C(sp(2))-H 活化和丙二酸酯偶联，随后进行分子内氧化 N-C 键形成。多种带有不同取代基的芳基被证明与该反应兼容。
