Kadota E, Maekura S, Hattori H, Horiuchi S, Hashimoto S
Second Department of Pathology, Kinki University School of Medicine, Osaka, Japan.
Neurol Res. 1989 Jun;11(2):114-7. doi: 10.1080/01616412.1989.11739873.
Experimental cerebral ischaemia was produced by microembolization in rats. HRP (horseradish peroxidase) was then injected into the cerebral cortex and the extracellular fluid dynamics were observed. In the control group, there was a basic pattern in the migration of the tracer. In the ischaemic group, a 'dense tracer distribution around the focus' was found in addition to the basic pattern. This phenomenon could be observed from the second day after the ischaemic insults. The perivascular DAB reaction was marked, particularly around the focus. There was a vesicular uptake of the tracer in the vascular endothelium. This phenomenon appeared almost simultaneously with the active resolution of the oedema fluid. In addition, frequent mitotic figures were seen around the focus. It was thus possible to hypothesize that the 'dense tracer distribution around the focus' appeared at the site of active tissue reaction and had a close relationship with oedema resolution.
通过微栓塞法在大鼠中制造实验性脑缺血。然后将辣根过氧化物酶（HRP）注入大脑皮层，并观察细胞外液动力学。在对照组中，示踪剂的迁移有一个基本模式。在缺血组中，除了基本模式外，还发现“病灶周围示踪剂分布密集”。这种现象在缺血损伤后第二天即可观察到。血管周围的二氨基联苯胺（DAB）反应明显，尤其是在病灶周围。在血管内皮中有示踪剂的囊泡摄取。这种现象几乎与水肿液的主动消退同时出现。此外，在病灶周围可见频繁的有丝分裂象。因此，可以推测“病灶周围示踪剂分布密集”出现在活跃的组织反应部位，并且与水肿消退密切相关。
