von Essen C, Elworthy P, Hitchcock E
Department of Neurosurgery, University of Birmingham, Warley, West Midlands, UK.
Neurol Res. 1989 Jun;11(2):76-8. doi: 10.1080/01616412.1989.11739866.
Red blood cell polyamine levels were followed in 13 patients treated with stereotactic radiosurgery for various types of brain tumours. In the most malignant tumours radiosurgery resulted in a decrease in spermine and an increase in spermidine levels. This discrepancy between variations in polyamine levels was not found after conventional radiotherapy. The results may indicate a change in tumour polyamine activity induced by high energy radiotherapy.
对13例接受立体定向放射外科治疗各种类型脑肿瘤的患者的红细胞多胺水平进行了跟踪监测。在最恶性的肿瘤中，放射外科治疗导致精胺水平降低，亚精胺水平升高。常规放疗后未发现多胺水平变化之间的这种差异。结果可能表明高能放疗诱导肿瘤多胺活性发生了变化。
