von Essen C, Elworthy P, Hitchcock E
University of Birmingham, Department of Neurosurgery, Smethwick, U.K.
Acta Neurochir (Wien). 1989;98(1-2):70-6. doi: 10.1007/BF01407180.
Red blood cell polyamine levels have been determined in patients with various histologically confirmed brain tumours. Increased spermine and spermidine levels were found in most patients with perifocal oedema demonstrated by CT; no correlation was found to other CT variables, nor to tumour localization. Polyamine levels increased during the clinical course coincident with tumour activity and decreased in response to surgery and radiotherapy. The response to chemotherapy involved a change in the relationship between spermine and spermidine levels. Our results underline the significance of regular polyamine level estimation during the management of patients with brain tumours.
已对经组织学确诊的各类脑肿瘤患者的红细胞多胺水平进行了测定。在多数经CT证实存在灶周水肿的患者中，发现精胺和亚精胺水平升高；未发现与其他CT变量以及肿瘤定位存在相关性。在临床病程中，多胺水平随肿瘤活动而升高，并在手术和放疗后降低。化疗反应涉及精胺和亚精胺水平之间关系的变化。我们的结果强调了在脑肿瘤患者管理过程中定期评估多胺水平的重要性。
