Wang Yajing, Shang Shuhuan, Li Chengzhang
Department of Periodontology, School and Hospital of Stomatology, Wuhan University, 237 Luo Yu Road, Wuhan 430079, People's Republic of China.
Curr Stem Cell Res Ther. 2016;11(1):3-18. doi: 10.2174/1574888x10666150220155921.
Ideal scaffolds for tissue engineering should have the same characteristics and morphology as the tissue. However, the microstructure of many native tissues has anisotropic characteristics, and the extracellular matrix has an orderly arrangement. Thus, aligned biomimetic scaffolds, a class of directional scaffolds, were proposed and researched to further mimic the permutations of tissue. This review covers the biomaterials, technology for the aligned biomimetic scaffolds and applications in tissue engineering. The aligned biomimetic scaffolds are extremely promising for tissue engineering because they can align the directions of cell growth, affect gene expression and significantly enhance cell reprogramming efficiency.
用于组织工程的理想支架应具有与组织相同的特性和形态。然而，许多天然组织的微观结构具有各向异性特征，且细胞外基质呈有序排列。因此，提出并研究了一类定向支架——排列仿生支架，以进一步模拟组织的排列。本文综述了排列仿生支架的生物材料、技术及其在组织工程中的应用。排列仿生支架在组织工程中极具前景，因为它们可以使细胞生长方向对齐，影响基因表达，并显著提高细胞重编程效率。
