Liu Mei, Zeng Xin, Ma Chao, Yi Huan, Ali Zeeshan, Mou Xianbo, Li Song, Deng Yan, He Nongyue
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering, Southeast University, Nanjing, PR China.
Nanjing Maternity and Child Health Care Hospital, Nanjing, PR China.
Bone Res. 2017 May 30;5:17014. doi: 10.1038/boneres.2017.14. eCollection 2017.
Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.
组织工程已成为修复受损软骨和骨组织的一种很有前景的策略。在用于组织工程应用的支架中，可注射水凝胶由于其高含水量、与天然细胞外基质（ECM）相似、具有用于细胞移植和增殖的多孔框架、微创特性以及匹配不规则缺损的能力，已在软骨和骨组织工程中显示出作为三维细胞培养支架的巨大潜力。在这篇综述中，我们描述了选择合适的生物材料和制备方法以制备用于软骨和骨组织工程的新型可注射水凝胶。此外，还总结了软骨生物学和骨ECM。最后，讨论了可注射水凝胶在软骨和骨组织工程中的未来前景。
