de Jesus Mariana Marcielo, Negrin Ana Carolina, Taboga Sebastião Roberto, Pinto-Fochi Maria Etelvina, Góes Rejane Maira
Department of Functional and Structural Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Department of Functional and Structural Biology, Institute of Biology, University of Campinas (UNICAMP), Campinas, SP, Brazil; Department of Biology, Institute of Biosciences, Humanities and Exact Sciences, Univ Estadual Paulista (UNESP), São José do Rio Preto, SP, Brazil.
Reprod Toxicol. 2015 Apr;52:26-39. doi: 10.1016/j.reprotox.2015.02.005. Epub 2015 Feb 17.
Both high-fat diet and exposure to endocrine-disrupting chemicals have been implicated in susceptibility to pathological prostate lesions, but the consequences of combining the two have not yet been examined. We evaluated the effects of gestational and postnatal exposure to a high-fat diet (20% fat) and low doses of di-n-butyl phthalate (DBP; 5mg/kg/day), individually or in combination, on the tissue response and incidence of pathological lesions in the ventral prostate of adult gerbils. Continuous intake of a high-fat diet caused dyslipidemia, hypertrophy, and promoted the development of inflammatory, premalignant and malignant prostate lesions, even in the absence of obesity. Life-time DBP exposure was obesogenic and dyslipidemic and increased the incidence of premalignant prostate lesions. Combined exposure to DBP and a high-fat diet also caused prostate hypertrophy, but the effects were less severe than those of individual treatments; combined exposure neither induced an inflammatory response nor altered serum lipid content.
高脂肪饮食和接触内分泌干扰化学物质都与前列腺病理性病变的易感性有关，但两者结合的后果尚未得到研究。我们评估了成年沙鼠孕期和产后单独或联合接触高脂肪饮食（20%脂肪）和低剂量邻苯二甲酸二丁酯（DBP；5mg/kg/天）对腹侧前列腺组织反应和病理性病变发生率的影响。持续摄入高脂肪饮食会导致血脂异常、前列腺肥大，并促进炎症性、癌前和恶性前列腺病变的发展，即使在没有肥胖的情况下也是如此。终生接触DBP会导致肥胖和血脂异常，并增加前列腺癌前病变的发生率。联合接触DBP和高脂肪饮食也会导致前列腺肥大，但其影响不如单独治疗严重；联合接触既不会引发炎症反应，也不会改变血脂含量。
