Stasheff S F, Anderson W W, Clark S, Wilson W A
Epilepsy Center, Veterans Administration Medical Center, Durham, NC 27705.
Science. 1989 Aug 11;245(4918):648-51. doi: 10.1126/science.2569762.
In an electrographic model of seizures in the hippocampal slice, both of the N-methyl-D-aspartate (NMDA) antagonists 2-amino-5-phosphonovaleric acid and 5-methyl-10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5,10-imine maleate (MK-801) prevented the progressive development of seizures but did not block previously induced seizures. Thus, a process dependent on the NMDA receptor-ionophore complex establishes a long-lasting, seizure-prone state; thereafter the seizures depend on non-NMDA receptor-ionophore mechanisms. This suggests that there is an important distinction between epileptogenesis and seizure expression and between antiepileptogenic and anticonvulsant pharmacological agents.
在海马切片癫痫发作的电图模型中，N-甲基-D-天冬氨酸（NMDA）拮抗剂2-氨基-5-磷酸基戊酸和马来酸5-甲基-10,11-二氢-5H-二苯并[a,d]环庚烯-5,10-亚胺（MK-801）均可阻止癫痫发作的进行性发展，但不能阻断先前诱发的癫痫发作。因此，一个依赖于NMDA受体-离子通道复合物的过程建立了一种持久的、易癫痫发作状态；此后癫痫发作依赖于非NMDA受体-离子通道机制。这表明癫痫发生与癫痫发作表现之间以及抗癫痫发生药物与抗惊厥药物之间存在重要区别。
