Seubert P, Larson J, Oliver M, Jung M W, Baudry M, Lynch G
Center for the Neurobiology of Learning and Memory, Bonney Center, University of California, Irvine 92717.
Brain Res. 1988 Sep 13;460(1):189-94. doi: 10.1016/0006-8993(88)91222-x.
Stimulation of N-methyl-D-aspartate (NMDA) receptors was found to induce proteolysis of brain spectrin in hippocampal slices. The effect was dependent upon extracellular calcium, blocked by the antagonist 2-amino-5-phosphonovalerate (AP5), and was not reproduced by potassium-induced depolarization. These results are consistent with the hypothesis that the involvement of NMDA receptors in plasticity and excitotoxicity is at least partially mediated by calcium-activated proteolysis of cytoskeletal proteins.
研究发现，刺激N-甲基-D-天冬氨酸（NMDA）受体可诱导海马切片中脑血影蛋白的蛋白水解。该效应依赖于细胞外钙，被拮抗剂2-氨基-5-磷酸戊酸（AP5）阻断，且钾诱导的去极化不能重现此效应。这些结果与以下假说一致，即NMDA受体在可塑性和兴奋性毒性中的作用至少部分是由细胞骨架蛋白的钙激活蛋白水解介导的。
