Yang B, Lu G W
Sheng Li Xue Bao. 1989 Apr;41(2):184-90.
Noradrenaline (NE), glucine (GLY), gamma-aminobutyric acid (GABA) and L-glutamic acid (L-GLU) were locally applied to the dorsal surface of lumbar spinal cord on anesthetized and immobilized rats and their effects on segmental (SP) and descending (DP) spinal field potentials were examined. Both waves N and P of SP and DP were reduced markedly in amplitudes following local application of NE. A significant decrease in amplitude of wave N and a remarkable increase in wave P in both SP and DP were shown during the application of GLY, GABA and L-GLU. The results suggest that these neurotransmitters may be involved in the generation of waves N and P, particularly affecting the activities of interneurons in the spinal dorsal horn.
在麻醉并固定的大鼠身上，将去甲肾上腺素（NE）、甘氨酸（GLY）、γ-氨基丁酸（GABA）和L-谷氨酸（L-GLU）局部应用于腰段脊髓背表面，并检测它们对节段性（SP）和下行性（DP）脊髓场电位的影响。局部应用NE后，SP和DP的N波和P波的幅度均显著降低。在应用GLY、GABA和L-GLU期间，SP和DP的N波幅度显著降低，P波显著增加。结果表明，这些神经递质可能参与了N波和P波的产生，尤其影响脊髓背角中间神经元的活动。
