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[大鼠暴露于生物活性物质后脊髓神经根反射放电和电紧张电位的变化]

[Changes in the reflex discharges and electrotonic potentials of spinal nerve roots in the rat upon exposure to biologically active substances].

作者信息

Abramets I I, Komissarov I V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1983 Nov;69(11):1433-40.

PMID:6197324
Abstract

The ionic nature of neuronal postsynaptic responses to monoamines, aminoacids and the substance P was studied in the newborn rat isolated spinal cord. The responses of motoneurons to GABA, glycine, noradrenaline and dopamine appeared to be Cl-dependent. The depolarization of motoneurons induced by L-glutamate and 5-hydroxytryptamine was Na-dependent whereas the same response to the substance P was Cl-dependent. Primary afferent depolarization with GABA is Cl-dependent whereas if induced by glycine and 5-hydroxytryptamine it is Na-dependent. Neurochemical and ionic profiles of mono- and polysynaptic ventral and dorsal root potentials are discussed.

摘要

在新生大鼠离体脊髓中研究了神经元对单胺、氨基酸和P物质的突触后反应的离子性质。运动神经元对γ-氨基丁酸（GABA）、甘氨酸、去甲肾上腺素和多巴胺的反应似乎依赖于氯离子。由L-谷氨酸和5-羟色胺诱导的运动神经元去极化依赖于钠离子，而对P物质的相同反应则依赖于氯离子。GABA引起的初级传入去极化依赖于氯离子，而由甘氨酸和5-羟色胺诱导时则依赖于钠离子。讨论了单突触和多突触腹根及背根电位的神经化学和离子特征。

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