Feng Mingbao, He Qun, Meng Lingjun, Zhang Xiaoling, Sun Ping, Wang Zunyao
State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Jiangsu Nanjing 210023, PR China.
Aquat Toxicol. 2015 Apr;161:108-16. doi: 10.1016/j.aquatox.2015.01.025. Epub 2015 Jan 29.
Perfluorooctane sulfonate, perfluorooctanoic acid, and copper have been recently regarded as ubiquitous environmental contaminants in aquatic ecosystems worldwide. However, data on their possible combined toxic effects on aquatic organisms are still lacking. In this study, a systematic experimental approach was used to assess the impacts of these chemicals and their mixtures on hepatic antioxidant status of Carassius auratus after 4 days. Oxidative stress was apparently observed for joint exposure by determining biochemical parameters (superoxide dismutase, catalase, glutathione peroxidase, reduced glutathione, and malondialdehyde). The integrated biomarker response index was calculated to rank the toxicity order, from which the synergistic effect was tentatively proposed for joint-toxicity action. In addition, these treatments significantly altered trace element homeostasis in different fish tissues, and the concentration distribution of these test chemicals was also measured. Taken together, these results provided some valuable toxicological data on the joint effects of perfluorinated compounds and heavy metals on aquatic species, which can facilitate further understanding on the potential risks of other coexisting pollutants in the natural aquatic environment.
全氟辛烷磺酸、全氟辛酸和铜最近被视为全球水生生态系统中普遍存在的环境污染物。然而，关于它们对水生生物可能的联合毒性效应的数据仍然缺乏。在本研究中，采用了一种系统的实验方法来评估这些化学物质及其混合物在4天后对鲫鱼肝脏抗氧化状态的影响。通过测定生化参数（超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、还原型谷胱甘肽和丙二醛），明显观察到联合暴露引起的氧化应激。计算综合生物标志物反应指数以对毒性顺序进行排名，据此初步提出联合毒性作用的协同效应。此外，这些处理显著改变了不同鱼类组织中的微量元素稳态，并且还测量了这些受试化学物质的浓度分布。综上所述，这些结果提供了一些关于全氟化合物和重金属对水生物种联合效应的有价值的毒理学数据，这有助于进一步了解自然水生环境中其他共存污染物的潜在风险。
