Choi Eue-Keun, Nagashima Koichi, Lin Kaity Y, Kumar Saurabh, Barbhaiya Chirag R, Baldinger Samuel H, Reichlin Tobias, Michaud Gregory F, Couper Gregory S, Stevenson William G, John Roy M
Cardiac Arrhythmia Division, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts; Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Cardiac Arrhythmia Division, Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts.
Heart Rhythm. 2015 Jun;12(6):1128-36. doi: 10.1016/j.hrthm.2015.02.016. Epub 2015 Feb 16.
Ventricular arrhythmias (VAs) from the left ventricular outflow tract (LVOT) region can be inaccessible for ablation because of epicardial fat or overlying coronary arteries.
We describe surgical cryoablation of this type of VA.
From March 2009 to 2014, 190 consecutive patients with VAs originating from the LVOT underwent ablation at our institution. Four patients (2%) underwent surgical cryoablation for highly symptomatic VAs after failing catheter ablation.
In all patients, endocardial or percutaneous epicardial mapping was consistent with origin in the LVOT. In 2 patients, the points of earliest activation during VAs were marked with a bipolar pacing lead in the overlying cardiac vein for guidance during surgery. Surgical cryoablation was successful in 3 of the 4 patients. The fourth patient subsequently had successful endocardial catheter ablation. During a mean follow-up of 22 ± 16 months (range 4-42 months), all patients showed abolition of or marked reduction in symptomatic VA. However, 1 patient subsequently required percutaneous intervention to the left anterior descending coronary artery; another developed progressive left ventricular systolic dysfunction caused by nonischemic cardiomyopathy; and a third patient underwent permanent pacemaker implantation because of complete atrioventricular block after concomitant aortic valve replacement.
Surgical cryoablation is an option for highly symptomatic drug-resistant VAs emanating from the LVOT region. Despite extensive preoperative mapping, the procedure is not effective for all patients, and coronary injury is a risk.
