Falusi A G, Esan G J
Postgraduate Institute of Medical Research and Training, College of Medicine, University College Hospital, Ibadan, Nigeria.
Trop Geogr Med. 1989 Apr;41(2):133-7.
The Hpa-I restriction fragment length polymorphism linked to the beta globin genes was studied in 181 Nigerian subjects. The beta S gene was found to be linked to the 13 kilobase (kb) Hpa-I fragment in 98.4 percent while 1.6 percent was linked to the Hpa-I 7.6 kb fragment. The majority of beta A genes (94.2%) was found to be linked to either the 7.6 or 7.0 kb fragment whilst the remainder (5.8%) was linked to the 13.0 kb. The beta A 13 kb linkage and the small proportion of the beta S genes linked to the 7.6 kb fragment would lessen the accuracy of the Hpa-I polymorphism in the prenatal diagnosis of sickle cell anaemia in this population.
在181名尼日利亚受试者中研究了与β珠蛋白基因相关的Hpa - I限制性片段长度多态性。发现98.4%的βS基因与13千碱基（kb）的Hpa - I片段相连，而1.6%与Hpa - I 7.6 kb片段相连。发现大多数βA基因（94.2%）与7.6或7.0 kb片段相连，其余（5.8%）与13.0 kb片段相连。βA 13 kb的连锁以及与7.6 kb片段相连的小比例βS基因会降低该人群中Hpa - I多态性在镰状细胞贫血产前诊断中的准确性。
