沙特人的β-珠蛋白基因多态性：5.6 Hpa I片段。

Beta-globin gene polymorphism in Saudis: 5.6 Hpa I fragment.

作者信息

el-Hazmi M A, Warsy A S

机构信息

College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Hum Hered. 1987;37(4):237-40. doi: 10.1159/000153710.

DOI:10.1159/000153710

PMID:2820866

Abstract

To investigate beta-globin gene polymorphism in the Saudi population, samples from 436 individuals from the eastern and north-western provinces of Saudi Arabia were studied using restriction endonucleases Mst II and Hpa I. Three individuals with haemoglobin genotypes AA, AS and SS were identified to each have a 5.6-kilobase (kb) Hpa I fragment in addition to a 13.0-kb fragment. This paper reports for the first time in Saudis a linkage of both the beta A and beta B genes to a 5.6-kb Hpa I fragment.

摘要

为研究沙特人群中的β-珠蛋白基因多态性，我们使用限制性内切酶Mst II和Hpa I对来自沙特阿拉伯东部和西北部省份的436名个体的样本进行了研究。鉴定出三名血红蛋白基因型分别为AA、AS和SS的个体，除了一个13.0千碱基（kb）的片段外，各自还有一个5.6千碱基的Hpa I片段。本文首次在沙特人中报道了βA和βB基因与一个5.6千碱基的Hpa I片段的连锁关系。