沙特人β-珠蛋白基因多态性——Hpa I三联体片段
Beta-globin gene polymorphism in Saudis--triple Hpa I fragments.
作者信息
el-Hazmi M A, Jabbar F A, Al-Swailem A R, Warsy A S
出版信息
Hum Genet. 1986 Nov;74(3):313-5. doi: 10.1007/BF00282555.
In an attempt to investigate beta-globin gene polymorphism in the Saudi population, DNA samples were analysed using restriction endonucleases, Mst II and Hpa I. Both beta A and beta S genes showed extensive polymorphism and were found to be linked to 13.0 kb, 7.6 kb, 7.0 kb, and 5.6 kb Hpa I fragments. Three DNA samples out of a total of 436 analysed, had beta-globin gene linked to three Hpa I fragments of the sizes 13.0 kb, 7.6 kb, and 5.6 kb. In this paper we present our findings and discuss the possibility of multiple beta-globin loci.
为了研究沙特人群中的β-珠蛋白基因多态性，使用限制性内切酶Mst II和Hpa I对DNA样本进行了分析。βA和βS基因均显示出广泛的多态性，并发现它们与13.0 kb、7.6 kb、7.0 kb和5.6 kb的Hpa I片段相连。在总共分析的436个DNA样本中，有3个样本的β-珠蛋白基因与大小为13.0 kb、7.6 kb和5.6 kb的三个Hpa I片段相连。在本文中，我们展示了我们的研究结果，并讨论了多个β-珠蛋白基因座的可能性。
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