Van Schinkel L D, Bakker L E H, Jonker J T, De Roos A, Pijl H, Meinders A E, Jazet I M, Lamb H J, Smit J W A
Department of Endocrinology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.
Department of Endocrinology, Leiden University Medical Center (LUMC), 2300 RC Leiden, The Netherlands.
Nutr Metab Cardiovasc Dis. 2015 Apr;25(4):403-10. doi: 10.1016/j.numecd.2014.12.007. Epub 2014 Dec 30.
South Asians have a higher risk of developing cardiovascular disease than white Caucasians. The underlying cause is unknown, but might be related to higher cardiac susceptibility to metabolic disorders. Short-term caloric restriction (CR) can be used as a metabolic stress test to study cardiac flexibility. We assessed whether metabolic and functional cardiovascular flexibility to CR differs between South Asians and white Caucasians.
Cardiovascular function and myocardial triglycerides were assessed using a 1.5T-MRI/S-scanner in 12 middle-aged overweight male South Asians and 12 matched white Caucasians before and after an 8-day very low calorie diet (VLCD). At baseline South Asians were more insulin resistant than Caucasians. Cardiac dimensions were smaller, despite correction for body surface area, and pulse wave velocity (PWV) in the distal aorta was higher in South Asians. Systolic and diastolic function, myocardial triglycerides and pericardial fat did not differ significantly between groups. After the VLCD body weight reduced on average by 4.0 ± 0.2 kg. Myocardial triglycerides increased in both ethnicities by 69 ± 18%, and diastolic function decreased although this was not significant in South Asians. However, pericardial fat and PWV in the proximal and total aorta were reduced in Caucasians only.
Myocardial triglyceride stores in middle-aged overweight and insulin resistant South Asians are as flexible and amenable to therapeutic intervention by CR as age-, sex- and BMI-matched but less insulin resistant white Caucasians. However, paracardial fat volume and PWV showed a differential effect in response to an 8-day VLCD in favor of Caucasians.
NTR 2473 (URL: http://www.trialregister.nl/trialreg/admin/rctsearch.asp?Term=2473).
南亚人患心血管疾病的风险高于白种人。其潜在原因尚不清楚，但可能与心脏对代谢紊乱的易感性较高有关。短期热量限制（CR）可作为一种代谢应激试验来研究心脏弹性。我们评估了南亚人和白种人对CR的代谢和功能性心血管弹性是否存在差异。
在12名中年超重男性南亚人和12名匹配的白种人进行为期8天的极低热量饮食（VLCD）前后，使用1.5T-MRI/S扫描仪评估心血管功能和心肌甘油三酯。基线时，南亚人的胰岛素抵抗比白种人更强。尽管校正了体表面积，但南亚人的心脏尺寸较小，且远端主动脉的脉搏波速度（PWV）较高。两组之间的收缩和舒张功能、心肌甘油三酯和心包脂肪无显著差异。VLCD后体重平均减轻4.0±0.2kg。两个种族的心肌甘油三酯均增加69±18%，舒张功能下降，尽管在南亚人组中不显著。然而，仅白种人的心包脂肪以及近端和总主动脉的PWV降低。
中年超重且胰岛素抵抗的南亚人的心肌甘油三酯储存与年龄、性别和BMI匹配但胰岛素抵抗较低的白种人一样，对CR治疗干预具有弹性且易于接受。然而，心包脂肪体积和PWV对为期8天的VLCD的反应存在差异，白种人更有利。
NTR 2473（网址：http://www.trialregister.nl/trialreg/admin/rctsearch.asp?Term=2473）
