Aytaç Erman, Büyüktaş Deram, Baysal Birol, Atar Murat, Yıldız Mustafa, Baca Bilgi, Karahasanoğlu Tayfun, Çelik Aykut, Seymen Hakki Oktay, Hamzaoğlu İsmail
Department of General Surgery, İstanbul University Cerrahpaşa Medical Faculty, İstanbul, Turkey.
Turk J Gastroenterol. 2015 Jan;26(1):15-9. doi: 10.5152/tjg.2015.4349.
BACKGROUND/AIMS: Data about the effects of inflammatory bowel disease (IBD) on various functions of the nervous and cardiovascular systems are limited. In this study, the visual neuronal and cardiovascular functions of patients with IBD were evaluated by measuring visual evoked potentials (VEP) and pulse wave velocity (PWV), respectively.
There were three study groups: the Crohn's disease (CD) group (n=25), the ulcerative colitis (UC) group (n=30), and a healthy control (C) group (n=25). The exclusion criteria were as follows: patients with IBD were in remission, had no extra-intestinal manifestations of the disease, had no additional chronic disease(s), and had been receiving medical treatment for their IBD without any previous surgical intervention. VEP amplitudes (mV) and the N2 and P2 latencies (ms) were recorded for visual-neuronal analysis of all study groups. For cardiovascular assessment in all study groups, PWV was measured noninvasively as follows: the carotid-femoral PWV with the Complior Colson device (The authors have no conflict of interest.) and the PWV along the aorta with two ultrasound strain-gauge pressure-sensitive transducers (TY-306 Fukuda pressure-sensitive transducers - Fukuda Denshi Co, Tokyo, Japan) fixed transcutaneously over the course of a pair of arteries separated by a known distance. The right femoral and right common carotid arteries were the ones used.
The PWV levels of the CD and UC groups were significantly higher than those in the C group (p<0.001). In the bilateral recording of the VEP, the N2 latencies of the CD (p<0.05) and UC (p<0.01) groups were significantly longer than those in the C group.
In this study, we showed vascular and visual neuronal impairments at a subclinical stage in patients with both types of IBD.
背景/目的：关于炎症性肠病（IBD）对神经和心血管系统各种功能影响的数据有限。在本研究中，分别通过测量视觉诱发电位（VEP）和脉搏波速度（PWV）来评估IBD患者的视觉神经元和心血管功能。
有三个研究组：克罗恩病（CD）组（n = 25）、溃疡性结肠炎（UC）组（n = 30）和健康对照组（C组，n = 25）。排除标准如下：IBD患者处于缓解期，无该疾病的肠外表现，无其他慢性疾病，且在没有任何先前手术干预的情况下接受IBD治疗。记录所有研究组的VEP振幅（mV）以及N2和P2潜伏期（ms）用于视觉神经元分析。对于所有研究组的心血管评估，采用无创方式测量PWV如下：使用Complior Colson设备测量颈股PWV（作者无利益冲突），并使用两个超声应变计压敏换能器（TY - 306福田压敏换能器 - 日本东京福田电子株式会社）经皮固定在一对相距已知距离的动脉上测量沿主动脉的PWV。使用的是右股动脉和右颈总动脉。
CD组和UC组的PWV水平显著高于C组（p < 0.001）。在VEP的双侧记录中，CD组（p < 0.05）和UC组（p < 0.01）的N2潜伏期显著长于C组。
在本研究中，我们显示了两种类型IBD患者在亚临床阶段存在血管和视觉神经元损伤。
