Demir Nazlı, Ahıshalı Emel, Dolapçıoğlu Can, Ercan Şerif, Orçun Kaptanağası Asuman, Dabak Reşat, Yücel Nihal, Sargın Mehmet, Uygur Bayramiçli Oya
Department of Gastroenterology, Dr. Lütfi Kırdar Kartal Education and Research Hospital, İstanbul, Turkey.
Turk J Gastroenterol. 2015 Jan;26(1):20-4. doi: 10.5152/tjg.2015.3626.
BACKGROUND/AIMS: The relationship between adipocytokines and the development of colorectal cancer is well-documented. Our aim was to assess the relationship among serum adiponectin and resistin levels, insulin resistance, and colorectal adenoma to evaluate whether these parameters can be used as biomarkers to predict the development of colorectal adenoma.
This is a cross-sectional case-control study conducted in 32 patients with colorectal adenoma and 30 control subjects. Serum adiponectin and resistin levels, body mass index values, waist and hip circumferences and Homeostasis Model Assessment scores were measured.
Resistin levels were slightly higher and adiponectin was slightly lower in patients with colorectal adenoma compared with controls; however, the differences in both parameters failed to reach statistical significance. The body mass index values and waist circumference of the patient group were significantly higher than controls (p=0.003 and p=0.002, respectively). Fasting serum insulin levels and Homeostasis Model Assessment scores of patients with colorectal adenoma were significantly higher than those of controls (p=0.02 and p=0.02, respectively). There was no relation between the number of colorectal adenomas and serum adiponectin or resistin levels.
Our data indicate that obesity and insulin resistance may contribute to the development of colorectal adenoma and that serum adiponectin levels and insulin resistance may not have a substantial predictive value for colorectal adenoma.
背景/目的：脂肪细胞因子与结直肠癌发生之间的关系已有充分文献记载。我们的目的是评估血清脂联素和抵抗素水平、胰岛素抵抗与结直肠腺瘤之间的关系，以评估这些参数是否可作为预测结直肠腺瘤发生的生物标志物。
这是一项横断面病例对照研究，纳入32例结直肠腺瘤患者和30例对照者。测量血清脂联素和抵抗素水平、体重指数值、腰围和臀围以及稳态模型评估得分。
与对照组相比，结直肠腺瘤患者的抵抗素水平略高，脂联素水平略低；然而，这两个参数的差异均未达到统计学意义。患者组的体重指数值和腰围显著高于对照组（分别为p = 0.003和p = 0.002）。结直肠腺瘤患者的空腹血清胰岛素水平和稳态模型评估得分显著高于对照组（分别为p = 0.02和p = 0.02）。结直肠腺瘤的数量与血清脂联素或抵抗素水平之间无关联。
我们的数据表明，肥胖和胰岛素抵抗可能促进结直肠腺瘤的发生，且血清脂联素水平和胰岛素抵抗对结直肠腺瘤可能没有实质性的预测价值。
