Bjurlin Marc A, McClintock Tyler R, Stifelman Michael D
Division of Urology, Department of Surgery, SBH Health System, Bronx, NY, USA.
Curr Urol Rep. 2015 Apr;16(4):20. doi: 10.1007/s11934-015-0495-9.
Near-infrared fluorescence (NIRF) imaging with intraoperative administration of indocyanine green (ICG) is a technology with emerging applications in urologic surgery. ICG is a water-soluble dye that fluoresces bright green when viewed under near-infrared light (700-1000 nm). This technology has been applied to robotic partial nephrectomy, first to potentially allow for the differentiation of renal tumor from normal parenchyma. In this application, it has been hypothesized that normal kidney tissue fluoresces green, while the tumor commonly remains hypofluorescent, thereby aiding tumor excision. Secondly, NIRF imaging with ICG has been employed to facilitate selective arterial clamping during robotic partial nephrectomy, allowing for a regional perfusion deficit in the kidney to be readily identified and therefore targeted at a given tumor. Recent studies have shown the associated decrease in global ischemia to minimize resultant loss of renal function at certain time endpoints. This review presents the most recent studies and evidence on the intraoperative administration of indocyanine green for robotic partial nephrectomy.
术中给予吲哚菁绿（ICG）的近红外荧光（NIRF）成像技术在泌尿外科手术中的应用正在兴起。ICG是一种水溶性染料，在近红外光（700 - 1000 nm）下观察时会发出亮绿色荧光。该技术已应用于机器人辅助部分肾切除术，首先可能用于区分肾肿瘤与正常肾实质。在这种应用中，据推测正常肾组织会发出绿色荧光，而肿瘤通常荧光较弱，从而有助于肿瘤切除。其次，ICG的NIRF成像已被用于在机器人辅助部分肾切除术中促进选择性动脉夹闭，使肾脏局部灌注不足易于识别，从而针对特定肿瘤进行处理。最近的研究表明，在特定时间点，相关的全身缺血减少可将肾功能的最终损失降至最低。本综述介绍了关于术中给予吲哚菁绿用于机器人辅助部分肾切除术的最新研究和证据。
