Walther Sebastian, Stegmayer Katharina, Horn Helge, Rampa Luca, Razavi Nadja, Müller Thomas J, Strik Werner
University Hospital of Psychiatry, University of Bern , Bern , Switzerland.
Front Psychiatry. 2015 Feb 5;6:10. doi: 10.3389/fpsyt.2015.00010. eCollection 2015.
Schizophrenia is associated with heterogeneous course of positive and negative symptoms. In addition, reduced motor activity as measured by wrist actigraphy has been reported. However, longitudinal studies of spontaneous motor activity are missing. We aimed to explore whether activity levels were stable within and between psychotic episodes. Furthermore, we investigated the association with the course of negative symptoms. In 45 medicated patients, we investigated motor behavior within a psychotic episode. In addition, we followed 18 medicated patients across 2 episodes. Wrist actigraphy and psychopathological ratings were applied. Within an episode symptoms changed but activity levels did not vary systematically. Activity at baseline predicted the course of negative symptoms. Between two episodes activity recordings were much more stable. Again, activity at the index episode predicted the outcome of negative symptoms. In sum, spontaneous motor activity shares trait and state characteristics, the latter are associated with negative symptom course. Actigraphy may therefore become an important ambulatory instrument to monitor negative symptoms and treatment outcome in schizophrenia.
精神分裂症与阳性和阴性症状的异质性病程相关。此外，据报道，通过手腕活动记录仪测量的运动活动减少。然而，缺乏对自发运动活动的纵向研究。我们旨在探讨精神病发作期间及发作之间的活动水平是否稳定。此外，我们研究了与阴性症状病程的关联。在45名接受药物治疗的患者中，我们调查了精神病发作期间的运动行为。此外，我们对18名接受药物治疗的患者进行了两次发作的随访。应用了手腕活动记录仪和精神病理学评分。在一次发作期间，症状发生了变化，但活动水平没有系统性变化。基线时的活动可预测阴性症状的病程。在两次发作之间，活动记录更为稳定。同样，首次发作时的活动可预测阴性症状的结果。总之，自发运动活动具有特质和状态特征，后者与阴性症状病程相关。因此，活动记录仪可能成为监测精神分裂症阴性症状和治疗结果的重要动态工具。
