B族G蛋白偶联受体的寡聚化：家族间寡聚体形成的探索
Oligomerization of Family B GPCRs: Exploration in Inter-Family Oligomer Formation.
作者信息
Ng Hans K H, Chow Billy K C
机构信息
Department of Endocrinology, School of Biological Sciences, The University of Hong Kong , Hong Kong , China.
出版信息
Front Endocrinol (Lausanne). 2015 Feb 2;6:10. doi: 10.3389/fendo.2015.00010. eCollection 2015.
Abstract
G-protein-coupled receptors (GPCRs) are classified into A to F subfamilies in which only families A, B, and C are present in mammals. Some of these GPCRs were found to form higher ordered structures such as oligomers with the discovery of interacting receptors in the form of homomers or heteromers. The importance of these oligomers on regulating receptor functions has recently been an intense research focus. It has been proposed that receptor oligomer formation has impact on its physiological importance on receptor trafficking, signaling, ligand-related regulation, and also is related to certain diseases. The present body of knowledge, however, comprises mainly intra-family oligomers formation and their consequences. Inter-family oligomers are recognized but there is limited information. This article aims to provide a current view regarding inter-family GPCR oligomerization in the subfamilies A, B, and C found in mammals.
摘要
G蛋白偶联受体（GPCRs）被分为A至F亚家族，其中只有A、B和C家族存在于哺乳动物中。随着以同源二聚体或异源二聚体形式相互作用的受体的发现，人们发现其中一些GPCRs会形成更高阶的结构，如寡聚体。这些寡聚体对调节受体功能的重要性最近成为了一个研究热点。有人提出，受体寡聚体的形成会影响其在受体运输、信号传导、配体相关调节方面的生理重要性，并且还与某些疾病有关。然而，目前的知识体系主要包括家族内寡聚体的形成及其后果。跨家族寡聚体已被认识到，但相关信息有限。本文旨在提供关于在哺乳动物中发现的A、B和C亚家族跨家族GPCR寡聚化的当前观点。
相似文献
1
Oligomerization of Family B GPCRs: Exploration in Inter-Family Oligomer Formation.B族G蛋白偶联受体的寡聚化：家族间寡聚体形成的探索
Front Endocrinol (Lausanne). 2015 Feb 2;6:10. doi: 10.3389/fendo.2015.00010. eCollection 2015.
2
Oligomerization of GPCRs involved in endocrine regulation.参与内分泌调节的G蛋白偶联受体的寡聚化。
J Mol Endocrinol. 2016 Jul;57(1):R59-80. doi: 10.1530/JME-16-0049. Epub 2016 May 5.
3
G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives.G蛋白偶联受体寡聚化再探讨：功能与药理学视角
Pharmacol Rev. 2014 Feb 10;66(2):413-34. doi: 10.1124/pr.113.008052. Print 2014.
4
Current Techniques for Studying Oligomer Formations of G-Protein-Coupled Receptors Using Mammalian and Yeast Cells.利用哺乳动物细胞和酵母细胞研究G蛋白偶联受体寡聚体形成的当前技术
Curr Med Chem. 2016 May 27;23(16):1638-56. doi: 10.2174/0929867323666160407113353.
5
Receptor oligomerization in family B1 of G-protein-coupled receptors: focus on BRET investigations and the link between GPCR oligomerization and binding cooperativity.B1 家族 G 蛋白偶联受体的受体寡聚化：BRET 研究的焦点及 GPCR 寡聚化与结合协同性之间的联系。
Front Endocrinol (Lausanne). 2012 May 7;3:62. doi: 10.3389/fendo.2012.00062. eCollection 2012.
6
Biochemical assay of G protein-coupled receptor oligomerization: adenosine A1 and thromboxane A2 receptors form the novel functional hetero-oligomer.G蛋白偶联受体寡聚化的生化分析：腺苷A1受体与血栓素A2受体形成新型功能性异源寡聚体。
Methods Cell Biol. 2013;117:213-27. doi: 10.1016/B978-0-12-408143-7.00012-8.
7
An update on the physiological and therapeutic relevance of GPCR oligomers.G蛋白偶联受体寡聚体的生理及治疗相关性最新进展。
Pharmacol Res. 2017 Mar;117:303-327. doi: 10.1016/j.phrs.2017.01.008. Epub 2017 Jan 11.
8
Overcoming the Challenges of Detecting GPCR Oligomerization in the Brain.克服在大脑中检测 GPCR 寡聚化的挑战。
Curr Neuropharmacol. 2022;20(6):1035-1045. doi: 10.2174/1570159X19666211104145727.
9
Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation.胰高血糖素受体家族中的侧向变构作用：胰高血糖素样肽 1 诱导 G 蛋白偶联受体形成异源二聚体。
Mol Pharmacol. 2012 Mar;81(3):309-18. doi: 10.1124/mol.111.074757. Epub 2011 Nov 22.
10
G protein-coupled receptor heteromer identification technology: identification and profiling of GPCR heteromers.G蛋白偶联受体异聚体鉴定技术：GPCR异聚体的鉴定与分析
J Lab Autom. 2011 Aug;16(4):285-91. doi: 10.1016/j.jala.2011.03.002. Epub 2011 May 31.
引用本文的文献
1
Chemokinergic and Dopaminergic Signalling Collaborates through the Heteromer Formed by CCR9 and Dopamine Receptor D5 Increasing the Migratory Speed of Effector CD4 T-Cells to Infiltrate the Colonic Mucosa.趋化因子和多巴胺能信号通过 CCR9 和多巴胺受体 D5 形成的异源二聚体协同作用，增加效应性 CD4 T 细胞的迁移速度，使其浸润结肠黏膜。
Int J Mol Sci. 2024 Sep 18;25(18):10022. doi: 10.3390/ijms251810022.
2
GPR43 stimulation on TCRαβ intraepithelial colonic lymphocytes inhibits the recruitment of encephalitogenic T-cells into the central nervous system and attenuates the development of autoimmunity.GPR43 刺激 TCRαβ 上皮内结肠淋巴细胞可抑制致脑炎 T 细胞向中枢神经系统的募集，并减轻自身免疫的发展。
J Neuroinflammation. 2023 Jun 1;20(1):135. doi: 10.1186/s12974-023-02815-9.
3
New Insights into the Structure and Function of Class B1 GPCRs.B1 类 G 蛋白偶联受体的结构与功能的新见解。
Endocr Rev. 2023 May 8;44(3):492-517. doi: 10.1210/endrev/bnac033.
4
Angiotensin and Endothelin Receptor Structures With Implications for Signaling Regulation and Pharmacological Targeting.血管紧张素和内皮素受体结构及其对信号调节和药物靶向的影响。
Front Endocrinol (Lausanne). 2022 Apr 19;13:880002. doi: 10.3389/fendo.2022.880002. eCollection 2022.
5
Receptor-Receptor Interactions as a Widespread Phenomenon: Novel Targets for Drug Development?受体-受体相互作用作为一种普遍现象：药物开发的新靶点？
Front Endocrinol (Lausanne). 2019 Feb 18;10:53. doi: 10.3389/fendo.2019.00053. eCollection 2019.
6
Immune signalling by supramolecular assemblies.超分子组装的免疫信号传导。
Immunology. 2018 Dec;155(4):435-445. doi: 10.1111/imm.12995. Epub 2018 Sep 24.
7
Structural-Functional Features of the Thyrotropin Receptor: A Class A G-Protein-Coupled Receptor at Work.促甲状腺激素受体的结构功能特征：发挥作用的A类G蛋白偶联受体
Front Endocrinol (Lausanne). 2017 Apr 24;8:86. doi: 10.3389/fendo.2017.00086. eCollection 2017.
8
Disruption of Rhodopsin Dimerization with Synthetic Peptides Targeting an Interaction Interface.利用靶向相互作用界面的合成肽破坏视紫红质二聚化
J Biol Chem. 2015 Oct 16;290(42):25728-44. doi: 10.1074/jbc.M115.662684. Epub 2015 Sep 1.
本文引用的文献
1
Transmembrane peptides as unique tools to demonstrate the in vivo action of a cross-class GPCR heterocomplex.跨膜肽作为一种独特的工具，用于证明跨类GPCR异源复合物的体内作用。
FASEB J. 2014 Jun;28(6):2632-44. doi: 10.1096/fj.13-246868. Epub 2014 Mar 5.
2
Efficacy as an intrinsic property of the M(2) muscarinic receptor in its tetrameric state.作为 M2 毒蕈碱型乙酰胆碱受体四聚体固有特性的效能。
Biochemistry. 2013 Oct 22;52(42):7405-27. doi: 10.1021/bi4003869. Epub 2013 Oct 11.
3
Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery.胰高血糖素样肽-1 受体二聚化差异调节激动剂信号转导，但不影响小分子变构。
Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18607-12. doi: 10.1073/pnas.1205227109. Epub 2012 Oct 22.
4
Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1 induces G-protein-coupled receptor heteromer formation.胰高血糖素受体家族中的侧向变构作用：胰高血糖素样肽 1 诱导 G 蛋白偶联受体形成异源二聚体。
Mol Pharmacol. 2012 Mar;81(3):309-18. doi: 10.1124/mol.111.074757. Epub 2011 Nov 22.
5
The oligomeric state sets GABA(B) receptor signalling efficacy.寡聚状态设定 GABA(B) 受体信号转导效率。
EMBO J. 2011 May 6;30(12):2336-49. doi: 10.1038/emboj.2011.143.
6
An indispensable role of secretin in mediating the osmoregulatory functions of angiotensin II.在介导血管紧张素 II 的渗透压调节功能方面，分泌素起着不可或缺的作用。
FASEB J. 2010 Dec;24(12):5024-32. doi: 10.1096/fj.10-165399. Epub 2010 Aug 25.
7
Fluorescent protein complementation assays: new tools to study G protein-coupled receptor oligomerization and GPCR-mediated signaling.荧光蛋白互补测定法：研究 G 蛋白偶联受体寡聚化和 GPCR 介导的信号转导的新工具。
Mol Cell Endocrinol. 2011 Jan 15;331(2):185-93. doi: 10.1016/j.mce.2010.07.011. Epub 2010 Jul 21.
8
Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.时间分辨荧光共振能量转移（FRET）技术揭示了天然组织中 G 蛋白偶联受体配体的寡聚体。
Nat Chem Biol. 2010 Aug;6(8):587-94. doi: 10.1038/nchembio.396. Epub 2010 Jul 11.
9
Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery.七跨膜受体作为构象变化蛋白：变构调节和功能选择性对新药发现的影响。
Pharmacol Rev. 2010 Jun;62(2):265-304. doi: 10.1124/pr.108.000992. Epub 2010 Apr 14.
10
Dimeric arrangement of the parathyroid hormone receptor and a structural mechanism for ligand-induced dissociation.甲状旁腺激素受体的二聚体排列和配体诱导解离的结构机制。
J Biol Chem. 2010 Apr 16;285(16):12435-44. doi: 10.1074/jbc.M109.093138. Epub 2010 Feb 19.
Zotero 插件