Söderberg-Nauclér Cecilia, Johnsen John Inge
Cecilia Söderberg-Nauclér, Experimental Cardiovascular Research Unit, Department of Medicine, Solna, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden.
World J Exp Med. 2015 Feb 20;5(1):1-10. doi: 10.5493/wjem.v5.i1.1.
During the last years increasing evidence implies that human cytomegalovirus (CMV) can be attributed to human malignancies arising from numerous tissues. In this perspective, we will review and discuss the potential mechanisms through which CMV infection may contribute to brain tumors by affecting tumor cell initiation, progression and metastasis formation. Recent evidence also suggests that anti-CMV treatment results in impaired tumor growth of CMV positive xenografts in animal models and potentially increased survival in CMV positive glioblastoma patients. Based on these observations and the high tumor promoting capacity of this virus, the classical and novel antiviral therapies against CMV should be revisited as they may represent a great promise for halting tumor progression and lower cancer deaths.
在过去几年中，越来越多的证据表明，人类巨细胞病毒（CMV）可能与源自多种组织的人类恶性肿瘤有关。从这个角度来看，我们将回顾并讨论CMV感染可能通过影响肿瘤细胞的起始、进展和转移形成而导致脑肿瘤的潜在机制。最近的证据还表明，抗CMV治疗会导致动物模型中CMV阳性异种移植物的肿瘤生长受损，并可能提高CMV阳性胶质母细胞瘤患者的生存率。基于这些观察结果以及该病毒强大的促肿瘤能力，针对CMV的经典和新型抗病毒疗法值得重新审视，因为它们可能为阻止肿瘤进展和降低癌症死亡率带来巨大希望。
