Department of Biotechnologies, Chemistry and Pharmacy, University of Siena Siena, Italy.
Department of Life Sciences and Biotechnology, University of Ferrara Ferrara, Italy.
Front Chem. 2015 Feb 2;3:4. doi: 10.3389/fchem.2015.00004. eCollection 2015.
A chronic increase of oxidative stress is typical of serious pathologies such as myocardial infarction, stroke, chronic limb ischemia, chronic obstructive pulmonary disease (COPD), type II-diabetes, age-related macular degeneration leads to an epic increase of morbidity and mortality in all countries of the world. The initial inflammation followed by an excessive release of reactive oxygen species (ROS) implies a diffused cellular injury that needs to be corrected by an inducible expression of the innate detoxifying and antioxidant system. The transcription factor Nrf2, when properly activated, is able to restore a redox homeostasis and possibly improve human health.
慢性氧化应激增加是心肌梗死、中风、慢性肢体缺血、慢性阻塞性肺疾病（COPD）、2 型糖尿病等严重疾病的典型特征，年龄相关性黄斑变性导致全世界所有国家的发病率和死亡率大幅上升。最初的炎症反应后，活性氧（ROS）的过度释放意味着弥漫性的细胞损伤，需要通过诱导固有解毒和抗氧化系统的表达来纠正。转录因子 Nrf2 被适当激活后，能够恢复氧化还原平衡，从而可能改善人类健康。
