Laboratory of Pharmacology and Experimental Therapeutics, IBILI, Medicine Faculty, University of Coimbra, Coimbra, Portugal.
Oxid Med Cell Longev. 2012;2012:741545. doi: 10.1155/2012/741545. Epub 2012 Aug 13.
Over the last 30 years the combination of both a sedentary lifestyle and excessive food availability has led to a significant increase in the prevalence of obesity and aggravation of rates of metabolic syndrome and type 2 diabetes mellitus (T2DM). Several lines of scientific evidence have been demonstrating that a low level of physical activity and decreased daily energy expenditure leads to the accumulation of visceral fat and, consequently, the activation of the oxidative stress/inflammation cascade, which underlies the development of insulin resistant T2DM and evolution of micro, and macrovascular complications. This paper focuses on the pathophysiological pathways associated with the involvement of oxidative stress and inflammation in the development of T2DM and the impact of regular physical exercise (training) as a natural antioxidant and anti-inflammatory strategy to prevent evolution of T2DM and its serious complications.
在过去的 30 年中，久坐的生活方式和过多食物的摄入这两者的结合导致肥胖的流行率显著增加，并且代谢综合征和 2 型糖尿病（T2DM）的发病率也有所加重。有几条科学证据表明，低水平的身体活动和日常能量消耗的减少会导致内脏脂肪的积累，从而激活氧化应激/炎症级联反应，这是胰岛素抵抗型 T2DM发展以及微、大血管并发症演变的基础。本文重点介绍与氧化应激和炎症参与 T2DM 发展相关的病理生理途径，以及定期体育锻炼（训练）作为一种天然抗氧化和抗炎策略对预防 T2DM 及其严重并发症发展的影响。
