Horjales-Araujo Emilia, Dahl Joergen B
Department of Anesthesia, Center of Head and Orthopedics, Copenhagen University Hospital, No. 4231, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Biomed Res Int. 2015;2015:349584. doi: 10.1155/2015/349584. Epub 2015 Jan 28.
It is suggested that genetic variations explain a significant portion of the variability in pain perception; therefore, increased understanding of pain-related genetic influences may identify new targets for therapies and treatments. The relative contribution of the different genes to the variance in clinical and experimental pain responses remains unknown. It is suggested that the genetic contributions to pain perception vary across pain modalities. For example, it has been suggested that more than 60% of the variance in cold pressor responses can be explained by genetic factors; in comparison, only 26% of the variance in heat pain responses is explained by these variations. Thus, the selection of pain model might markedly influence the magnitude of the association between the pain phenotype and genetic variability. Thermal pain sensation is complex with multiple molecular and cellular mechanisms operating alone and in combination within the peripheral and central nervous system. It is thus highly probable that the thermal pain experience is affected by genetic variants in one or more of the pathways involved in the thermal pain signaling. This review aims to present and discuss some of the genetic variations that have previously been associated with different experimental thermal pain models.
有人认为，基因变异在很大程度上解释了疼痛感知的变异性；因此，加深对疼痛相关基因影响的理解可能会确定新的治疗靶点。不同基因对临床和实验性疼痛反应差异的相对贡献仍不清楚。有人认为，基因对疼痛感知的贡献因疼痛模式而异。例如，有人提出，冷加压反应中超过60%的差异可由遗传因素解释；相比之下，热痛反应中只有26%的差异可由这些变异解释。因此，疼痛模型的选择可能会显著影响疼痛表型与基因变异性之间关联的程度。热痛觉很复杂，在外周和中枢神经系统中，多种分子和细胞机制单独或共同起作用。因此，热痛体验很可能受到热痛信号传导所涉及的一个或多个途径中的基因变异的影响。本综述旨在介绍和讨论一些先前与不同实验性热痛模型相关的基因变异。
