Cornelius Jack R, Kirisci Levent, Reynolds Maureen, Vanyukov Michael, Tarter Ralph
Center for Education and Drug Abuse Research (CEDAR), University of Pittsburgh , Pittsburgh, PA , USA.
Am J Drug Alcohol Abuse. 2015 May;41(3):264-8. doi: 10.3109/00952990.2015.1011744. Epub 2015 Feb 20.
Our previous work demonstrated that the Transmissible Liability Index (TLI), an instrument designed as an index of liability for substance use disorder (SUD), is associated with risk of substance use disorder. This longitudinal study assessed whether TLI measured in 10-12-year-olds (late childhood) predicts suicidal behavior from age 12-14 (preadolescence) to age 25 (young adulthood). We hypothesized that TLI would predict number and severity of suicide attempts.
Subjects were sons of men who had lifetime history of SUD (n = 250), called the High Average Risk (HAR) group, and sons of men with no lifetime history of a SUD (n = 250), called the Low Average Risk (LAR) group. The TLI was delineated at baseline (age 10-12), and age-specific versions were administered at 12-14, 16, 19, 22, and 25 years of age.
TLI was significantly associated with number and severity of lifetime suicide attempts.
These findings confirm the hypothesis that TLI assessed at late childhood is a predictor of frequency and severity of suicidal behavior from preadolescence to young adulthood.
我们之前的研究表明，可传播责任指数（TLI），一种被设计为物质使用障碍（SUD）责任指数的工具，与物质使用障碍风险相关。这项纵向研究评估了在10至12岁儿童期测量的TLI是否能预测从12至14岁青春期前期到25岁青年期的自杀行为。我们假设TLI能预测自杀未遂的次数和严重程度。
研究对象为有物质使用障碍终生史男性的儿子（n = 250），称为高平均风险（HAR）组，以及无物质使用障碍终生史男性的儿子（n = 250），称为低平均风险（LAR）组。在基线（10至12岁）时划定TLI，并在12至14岁、16岁、19岁、22岁和25岁时使用特定年龄版本进行测量。
TLI与终生自杀未遂的次数和严重程度显著相关。
这些发现证实了以下假设，即在儿童晚期评估的TLI是青春期前期到青年期自杀行为频率和严重程度的一个预测指标。
