评估胰蛋白酶样免疫反应性作为青少年向青年期过渡期间寻求药物使用障碍治疗的预测指标。
Assessing TLI as a Predictor of Treatment Seeking for SUD among Youth Transitioning to Young Adulthood.
作者信息
Cornelius Jack R, Kirisci Levent
机构信息
Center for Education and Drug Abuse Research (CEDAR) University of Pittsburgh, 3811 O'Hara Street, PAARC Suite, Pittsburgh, PA 15213, USA.
出版信息
Adv Psychol Res. 2013;98:85-94.
BACKGROUND
To date, few studies have been conducted evaluating predictors of treatment seeking for substance use disorders as persons make the transition from preadolescence (a period of very low substance use) to young adulthood (a period of peak substance use). The few studies of this area which have been conducted to date have generally been limited by their use of a cross-sectional rather than a longitudinal study design. We have conducted a longitudinal etiology study (CEDAR) to assess whether an index of behavioral undercontrol called the Transmissible Liability Index (TLI) measured during preadolescence serves as a predictor of the development of substance use disorders (SUD) and of treatment utilization during young adulthood. Our recent work has focuses on subjects with cannabis use disorders (CUD), since CUD are the most common SUD. In recent analyses, we found that TLI serves as a predictor of the development of cannabis use disorder (CUD) among young adults (Kirisci et al., 2009).
OBJECTIVE
In the current study, we hypothesized that TLI as assessed during preadolescence would predict treatment seeking a decade later when the subjects were young adults.
METHOD
The 375 participants in this study were initially recruited when they were 10-12 years of age. TLI status was determined at baseline, and subsequent assessments were conducted at 12-14, 16, 19, and 22 years of age. Variables examined included TLI as well as demographic variables. Path analyses were conducted.
RESULTS
Of the 375 subjects recruited at age 10-12, 92 subjects (24.5%) were diagnosed with a CUD by the age of 22. TLI as assessed during pre-adolescence (at age 10 to 12) was found to be associated with substance-related treatment during young adulthood (age 19 and at age 22).
CONCLUSIONS
These findings confirmed our hypothesis that TLI assessed during preadolescent years serves as a predictor of treatment at age 19 and at age 22.
背景
迄今为止，很少有研究评估在从青春期前（物质使用水平极低的时期）到青年期（物质使用达到峰值的时期）过渡过程中，物质使用障碍寻求治疗的预测因素。该领域迄今为止所进行的少数研究通常受到其采用横断面而非纵向研究设计的限制。我们开展了一项纵向病因学研究（CEDAR），以评估在青春期前测量的一种称为可传递责任指数（TLI）的行为控制不足指标是否可作为青年期物质使用障碍（SUD）发展及治疗利用情况的预测因素。我们最近的工作聚焦于患有大麻使用障碍（CUD）的受试者，因为CUD是最常见的SUD。在最近的分析中，我们发现TLI可作为青年人大麻使用障碍（CUD）发展的预测因素（Kirisci等人，2009年）。
目的
在本研究中，我们假设青春期前评估的TLI将预测十年后受试者成年时的治疗寻求情况。
方法
本研究的375名参与者最初招募于10 - 12岁时。在基线时确定TLI状态，并在12 - 14岁、16岁、19岁和22岁时进行后续评估。所检查的变量包括TLI以及人口统计学变量。进行了路径分析。
结果
在10 - 12岁招募的375名受试者中，92名受试者（24.5%）在22岁时被诊断患有CUD。青春期前（10至12岁）评估的TLI被发现与青年期（19岁和22岁）与物质相关的治疗有关。
结论
这些发现证实了我们的假设，即青春期前评估的TLI可作为19岁和22岁时治疗的预测因素。
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