• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人类免疫球蛋白IGHG基因的BamHI和SacI限制性片段长度多态性与非洲人群Gm多态性的关系。主要多态性的证据。

BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.

作者信息

Ghanem N, Bensmana M, Dugoujon J M, Constans J, Lefranc M P, Lefranc G

机构信息

Laboratoire d'Immunogénétique, URA CNRS 1191, Université des Sciences et Techniques du Languedoc, Montpellier, France.

出版信息

Hum Genet. 1989 Aug;83(1):37-44. doi: 10.1007/BF00274144.

DOI:10.1007/BF00274144
PMID:2570016
Abstract

In this paper, we extend the study of the IGHG gene RFLPs in black African persons and in some other individuals characterized by a Negroid admixture. We demonstrate a polymorphism that is much more important in black Africans, than in Caucasoids, mainly for the IGHG3 and G1 genes, the most 5' members of the IGHG multigene family. These genes encode for the IgG3 and IgG1 subclasses, which are of crucial biological importance.

摘要

在本文中，我们扩展了对黑非洲人群以及其他一些具有尼格罗人混合血统个体的IGHG基因限制性片段长度多态性（RFLPs）的研究。我们证明了一种多态性，这种多态性在黑非洲人中比在白种人中更为显著，主要体现在IGHG多基因家族中最靠近5'端的IGHG3和G1基因上。这些基因编码IgG3和IgG1亚类，它们具有至关重要的生物学意义。

相似文献

1
BamHI and SacI RFLPs of the human immunoglobulin IGHG genes with reference to the Gm polymorphism in African people. Evidence for a major polymorphism.人类免疫球蛋白IGHG基因的BamHI和SacI限制性片段长度多态性与非洲人群Gm多态性的关系。主要多态性的证据。
Hum Genet. 1989 Aug;83(1):37-44. doi: 10.1007/BF00274144.
2
BstEII restriction fragment alleles and haplotypes of the human IGHG genes with reference to the BamHI/SacI RFLPs and to the Gm polymorphism.参照BamHI/SacI限制性片段长度多态性（RFLPs）和Gm多态性的人类IGHG基因的BstEII限制性片段等位基因和单倍型
Exp Clin Immunogenet. 1989;6(1):39-54.
3
Spanish and African contribution to the genetic pool of the Canary islanders: data from GM and KM haplotypes and RFLPs in the immunoglobulin IGHG loci.西班牙人和非洲人对加那利群岛居民基因库的贡献：来自免疫球蛋白IGHG基因座中GM和KM单倍型及限制性片段长度多态性的数据。
Ann Hum Genet. 1998 Jan;62(Pt 1):33-45. doi: 10.1046/j.1469-1809.1998.6210033.x.
4
Restriction fragment haplotypes in the human immunoglobulin IGHG locus and their correlation with the Gm polymorphism.人类免疫球蛋白IGHG基因座中的限制性片段单倍型及其与Gm多态性的相关性。
Eur J Immunol. 1988 Jul;18(7):1067-72. doi: 10.1002/eji.1830180715.
5
DNA analysis of the immunoglobulin IGHG loci in a Mandenka population from eastern Senegal: correlation with Gm haplotypes and hypotheses for the evolution of the Ig CH region.对来自塞内加尔东部曼丁卡人群免疫球蛋白IGHG基因座的DNA分析：与Gm单倍型的相关性及Ig CH区域进化的假说
Hum Genet. 1996 Jul;98(1):36-47. doi: 10.1007/s004390050156.
6
A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons.一种具有IGHG4转换区和三个铰链外显子的人类免疫球蛋白IGHG3等位基因（Gmb0、b1、c3、c5、u）
Immunogenetics. 1989;30(4):250-7. doi: 10.1007/BF02421328.
7
A study of Gm allotypes and immunoglobulin heavy gamma IGHG genes in Berbers, Arabs and sub-Saharan Africans from Jerba Island, Tunisia.突尼斯杰尔巴岛柏柏尔人、阿拉伯人和撒哈拉以南非洲人的Gm同种异型及免疫球蛋白重链γ（IGHG）基因研究。
Eur J Immunogenet. 2001 Oct;28(5):531-8. doi: 10.1046/j.1365-2370.2001.00254.x.
8
Genetic diversity in Tunisia: a study based on the GM polymorphism of human immunoglobulins.突尼斯的遗传多样性：一项基于人类免疫球蛋白GM多态性的研究。
Hum Biol. 2004 Aug;76(4):559-67. doi: 10.1353/hub.2004.0054.
9
BamHI-SacI RFLP and Gm analysis of the immunoglobulin IGHG genes in the Northern Selkups (west Siberia): new haplotypes with deletion, duplication and triplication.
Hum Genet. 1999 Dec;105(6):530-41. doi: 10.1007/s004399900187.
10
Alternative G1m, G2m and G3m allotypes of IGHG genes correlate with atopic and nonatopic pathways of immune regulation in children with bronchial asthma.IGHG基因的替代G1m、G2m和G3m同种异型与支气管哮喘儿童免疫调节的特应性和非特应性途径相关。
Int Arch Allergy Immunol. 1998 Mar;115(3):215-9. doi: 10.1159/000023903.

引用本文的文献

1
Immunoglobulins or Antibodies: IMGT Bridging Genes, Structures and Functions.免疫球蛋白或抗体：国际免疫基因组学数据库（IMGT）连接基因、结构与功能
Biomedicines. 2020 Aug 31;8(9):319. doi: 10.3390/biomedicines8090319.
2
Molecular analysis of the T17 immunoglobulin CH multigene deletion (del A1-GP-G2-G4-E).T17免疫球蛋白CH多基因缺失（缺失A1-GP-G2-G4-E）的分子分析
Hum Genet. 1994 May;93(5):520-8. doi: 10.1007/BF00202816.
3
Molecular characterization of Gm(n+) and G2m(n-) allotypes.Gm(n+)和G2m(n-)同种异型的分子特征

本文引用的文献

1
Human IgG allotypes co-occurring in more than one IgG subclass.在不止一种IgG亚类中共存的人类IgG同种异型。
Vox Sang. 1982;43(6):301-9. doi: 10.1111/j.1423-0410.1982.tb00028.x.
2
Simultaneous absence of the human IgG1, IgG2, IgG4 and IgA1 subclasses: immunological and immunogenetical considerations.人类IgG1、IgG2、IgG4和IgA1亚类同时缺失：免疫学和免疫遗传学考量
Eur J Immunol. 1983 Mar;13(3):240-4. doi: 10.1002/eji.1830130312.
3
Inherited deletion of immunoglobulin heavy chain constant region genes in normal human individuals.
Immunogenetics. 1995;42(5):414-7. doi: 10.1007/BF00179404.
4
A human immunoglobulin IGHG3 allele (Gmb0,b1,c3,c5,u) with an IGHG4 converted region and three hinge exons.一种具有IGHG4转换区和三个铰链外显子的人类免疫球蛋白IGHG3等位基因（Gmb0、b1、c3、c5、u）
Immunogenetics. 1989;30(4):250-7. doi: 10.1007/BF02421328.
正常人类个体中免疫球蛋白重链恒定区基因的遗传性缺失。
Nature. 1982 Dec 23;300(5894):760-2. doi: 10.1038/300760a0.
4
Arrangement of human immunoglobulin heavy chain constant region genes implies evolutionary duplication of a segment containing gamma, epsilon and alpha genes.人类免疫球蛋白重链恒定区基因的排列意味着包含γ、ε和α基因的片段发生了进化性重复。
Nature. 1982 Dec 23;300(5894):709-13. doi: 10.1038/300709a0.
5
Gene deletion and gene duplication within the cluster of human heavy-chain genes. Selective absence of IgG sub-classes.人类重链基因簇内的基因缺失和基因重复。IgG亚类的选择性缺失。
J Immunogenet. 1980 Aug;7(4):285-99. doi: 10.1111/j.1744-313x.1980.tb00722.x.
6
Instability of the human immunoglobulin heavy chain constant region locus indicated by different inherited chromosomal deletions.不同遗传性染色体缺失表明人类免疫球蛋白重链恒定区基因座不稳定。
Mol Biol Med. 1983 Sep;1(2):207-17.
7
Analysis of a break in chromosome 14 mapping to the region of the immunoglobulin heavy chain locus.对映射到免疫球蛋白重链基因座区域的14号染色体断裂的分析。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):1997-2001. doi: 10.1073/pnas.80.7.1997.
8
Comparison of the hinge-coding segments in human immunoglobulin gamma heavy chain genes and the linkage of the gamma 2 and gamma 4 subclass genes.人类免疫球蛋白γ重链基因中铰链编码区段的比较以及γ2和γ4亚类基因的连锁关系
EMBO J. 1982;1(4):403-7. doi: 10.1002/j.1460-2075.1982.tb01182.x.
9
Restriction fragment length polymorphisms associated with immunoglobulin C gamma genes reveal linkage disequilibrium and genomic organization.与免疫球蛋白Cγ基因相关的限制性片段长度多态性揭示了连锁不平衡和基因组组织。
Proc Natl Acad Sci U S A. 1983 Nov;80(22):6952-6. doi: 10.1073/pnas.80.22.6952.
10
A genetic marker of human IgE heavy chains, Em(1).
Vox Sang. 1984;46(4):195-206. doi: 10.1111/j.1423-0410.1984.tb00075.x.