将含小鼠同源异型框基因Hox-3.3定位并区域性定位于小鼠染色体15E区。

Isolation and regional localization of the murine homeobox-containing gene Hox-3.3 to mouse chromosome region 15E.

作者信息

Schughart K, Pravtcheva D, Newman M S, Hunihan L W, Jiang Z L, Ruddle F H

机构信息

Department of Biology, Yale University, New Haven, Connecticut 06511.

出版信息

Genomics. 1989 Jul;5(1):76-83. doi: 10.1016/0888-7543(89)90089-x.

DOI:10.1016/0888-7543(89)90089-x

PMID:2570032

Abstract

A murine homeobox-containing cDNA clone has been isolated from an adult spinal cord library. Using in situ hybridization and somatic cell genetics techniques, the newly isolated homeobox gene has been mapped to mouse chromosome region 15E. Because of its chromosomal location, we called this gene locus Hox-3.3. Nucleotide sequence analysis revealed that the Hox-3.3 gene represents the murine cognate of the human homeobox gene c8. The presumptive organization of the murine Hox-3 homeobox gene cluster is discussed.

摘要

一个含有小鼠同源异型框的cDNA克隆已从成年脊髓文库中分离出来。利用原位杂交和体细胞遗传学技术，新分离出的同源异型框基因已被定位到小鼠染色体15E区域。由于其染色体定位，我们将这个基因位点命名为Hox-3.3。核苷酸序列分析表明，Hox-3.3基因代表人类同源异型框基因c8的小鼠同源基因。本文讨论了小鼠Hox-3同源异型框基因簇的推测组织形式。