系统性红斑狼疮（SLE）和CREST/进行性系统性硬化症（PSS）中Gm同种基因型分布及HLA-DR与Gm无相互作用

Gm allogenotype distribution and lack of HLA-DR, Gm interaction in SLE and CREST/PSS.

作者信息

Jazwinska E C, Dunckley H, Gatenby P A, Serjeantson S W

机构信息

Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra.

出版信息

Immunol Cell Biol. 1989 Aug;67 ( Pt 4):261-5. doi: 10.1038/icb.1989.39.

DOI:10.1038/icb.1989.39

PMID:2570039

Abstract

The distribution of Gm allogenotypes (Gm allotypes identified by IgCH restriction fragment length polymorphism (RFLP) analysis) was compared in 66 systemic lupus erythematosus (SLE) patients, 38 CREST/PSS group (P less than 0.05) but not in the SLE group. HLA-DR5 is significantly increased in frequency in this series of CREST/PSS patients compared to controls (P less than 0.001), and log linear regression analysis showed that although both DR5 and Gm homozygosity were significant factors determining disease susceptibility, there was no evidence of an interactive effect between these two groups of genes increasing the predisposition to CREST/PSS.

摘要

通过免疫球蛋白重链（IgCH）限制性片段长度多态性（RFLP）分析鉴定的Gm同种异型基因型的分布，在66例系统性红斑狼疮（SLE）患者、38例CREST/硬皮病患者和35例正常对照中进行了比较。与正常对照相比，CREST/硬皮病组中Gm纯合子的频率显著增加（P<0.05），但在SLE组中未增加。在这一系列CREST/硬皮病患者中，HLA-DR5的频率与对照组相比显著增加（P<0.001），对数线性回归分析表明，虽然DR5和Gm纯合性都是决定疾病易感性的重要因素，但没有证据表明这两组基因之间存在交互作用增加对CREST/硬皮病的易感性。