原发性肥胖症手术腔内治疗（POSE）手术：患者一年的体重减轻情况及安全性结果。
The Primary Obesity Surgery Endolumenal (POSE) procedure: one-year patient weight loss and safety outcomes.
作者信息
López-Nava Gontrand, Bautista-Castaño Inmaculada, Jimenez Amaya, de Grado Teresa, Fernandez-Corbelle Juan Pedro
机构信息
Bariatric Endoscopy Unit, Madrid Sanchinarro University Hospital, Madrid, Spain.
Bariatric Endoscopy Unit, Madrid Sanchinarro University Hospital, Madrid, Spain.
出版信息
Surg Obes Relat Dis. 2015 Jul-Aug;11(4):861-5. doi: 10.1016/j.soard.2014.09.026. Epub 2014 Oct 7.
BACKGROUND
Obesity is at epidemic proportions and increasing. Bariatric surgical procedures have demonstrated better durable weight loss than diet and exercise; however, risk may limit adoption of these procedures. Endoscopic procedures may offer less risk, lower cost, and satisfactory results, but limited safety and outcome data is available. The present report describes the Primary Obesity Surgery Endolumenal (POSE(™)) procedure, perioperative care, and 1-year safety and weight loss outcomes for a single center.
METHODS
One hundred forty-seven patients undergoing the POSE procedure between July 2011 and January 2013 were followed for 1 year. Overall patient status and weight data were collected at baseline and at 3, 6, and 12 months. Outcomes included change in total weight loss (TWL), percentage of TWL (%TWL), percentage of excess weight loss (%EWL), and adverse events.
RESULTS
Patients tolerated the procedure well with no serious short-term or long-term adverse events. All but 1 patient were discharged within 24 hours of the procedure. Baseline body mass index (BMI) was 38.0 ± 4.8 kg/m(2). Initial weight (106.8 ± 18.2 kg) was significantly reduced at 3, 6, and 12 months. At 1 year, 116 patients (79% of total) who were available for follow-up had a mean TWL of 16.6 ± 9.7 kg, %TWL of 15.1 ± 7.8, and %EWL of 44.9 ± 24.4.
CONCLUSION
After 1-year follow-up, POSE was considered an effective, safe and well tolerated procedure for the treatment of patients with obesity.
背景
肥胖呈流行趋势且不断增加。减肥手术已证明比饮食和运动能带来更持久的体重减轻；然而，风险可能会限制这些手术的采用。内镜手术可能风险更低、成本更低且效果令人满意，但可用的安全性和结果数据有限。本报告描述了单中心的原发性肥胖症手术腔内治疗（POSE(™)）手术、围手术期护理以及1年的安全性和体重减轻结果。
方法
对2011年7月至2013年1月期间接受POSE手术的147例患者进行了1年的随访。在基线以及3、6和12个月时收集了患者的总体状况和体重数据。结果包括总体体重减轻（TWL）的变化、TWL百分比（%TWL）、超重减轻百分比（%EWL）以及不良事件。
结果
患者对该手术耐受性良好，无严重的短期或长期不良事件。除1例患者外，所有患者均在手术后24小时内出院。基线体重指数（BMI）为38.0±4.8kg/m²。初始体重（106.8±18.2kg）在3、6和12个月时显著降低。1年后，116例（占总数的79%）可进行随访的患者平均TWL为16.6±9.7kg，%TWL为15.1±7.8，%EWL为44.9±24.4。
结论
经过1年的随访，POSE被认为是治疗肥胖患者的一种有效、安全且耐受性良好的手术。
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