Lee Bor-Jen, Lin Jun-Shuo, Lin Yi-Chin, Lin Ping-Ting
The Intensive Care Unit, Taichung Veterans General Hospital, Taichung, Taiwan.
School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.
Nutrition. 2015 Mar;31(3):475-9. doi: 10.1016/j.nut.2014.10.001. Epub 2014 Oct 16.
Inflammation mediators have been recognized as risk factors for the pathogenesis of coronary artery disease (CAD). The purpose of this study was to investigate the effect of L-carnitine supplementation (LC, 1000 mg/d) on inflammation markers in patients with CAD.
We enrolled 47 patients with CAD in the study. The patients with CAD were identified by cardiac catheterization as having <50% stenosis of one major coronary artery. The patients were randomly assigned to the placebo (n = 24) and LC (n = 23) groups and the intervention was administered for 12 wk. The levels of LC, antioxidant status (malondialdehyde and antioxidant enzymes activities), and inflammation markers (C-reactive protein [CRP], interleukin [IL]-6, and tumor necrosis factor [TNF]-α) were measured.
Thirty-nine participants completed the study (19 placebo; 20 LC). After LC supplementation, the levels of inflammation markers were significantly reduced compared with the baseline (CRP, P < 0.01; IL-6, P = 0.03; TNF-α, P = 0.07) and those in the placebo group (CRP, P < 0.05; IL-6, P = 0.04; TNF-α, P = 0.03). The levels of inflammation markers were significantly negatively correlated with the levels of LC and antioxidant enzymes activities (P < 0.05).
We suggest that LC supplementation, due to its antioxidant effects, may have potential utility to reduce inflammation in CAD.
炎症介质已被公认为冠状动脉疾病（CAD）发病机制的危险因素。本研究旨在探讨补充左旋肉碱（LC，1000毫克/天）对CAD患者炎症标志物的影响。
我们招募了47例CAD患者进行研究。通过心脏导管检查确定CAD患者的一条主要冠状动脉狭窄<50%。患者被随机分为安慰剂组（n = 24）和LC组（n = 23），并进行了12周的干预。测量了LC水平、抗氧化状态（丙二醛和抗氧化酶活性）以及炎症标志物（C反应蛋白[CRP]、白细胞介素[IL]-6和肿瘤坏死因子[TNF]-α）。
39名参与者完成了研究（19名安慰剂组；20名LC组）。补充LC后，炎症标志物水平与基线相比显著降低（CRP，P < 0.01；IL-6，P = 0.03；TNF-α，P = 0.07），与安慰剂组相比也显著降低（CRP，P < 0.05；IL-6，P = 0.04；TNF-α，P = 0.03）。炎症标志物水平与LC水平和抗氧化酶活性显著负相关（P < 0.05）。
我们认为，由于其抗氧化作用，补充LC可能对降低CAD患者的炎症具有潜在作用。
