Ganesh S, Murti Rao J M, Cowie V A
Barnsley Health Authority.
J Ment Defic Res. 1989 Aug;33 ( Pt 4):323-9. doi: 10.1111/j.1365-2788.1989.tb01481.x.
Sixty-six neuroleptic medicated mentally handicapped subjects in a hospital were studied to determine the prevalence of drug-induced akathisia. Tardive dyskinesia was also rated on the AIMS scale. Only motor manifestations of akathisia could be assessed as the subjective component of akathisia was difficult to elicit in this population with difficulties in verbal communication. As all the subjects had been on neuroleptics for at least 3 years, only chronic akathisia could be studied. Five subjects had akathisia. Correlational analysis did not reveal any specific associations with any of the demographic, clinical and pharmacological variables studied. A step-wise multiple regression analysis indicated that younger age could be a predictor. Tardive dyskinesia was associated in two of the subjects. The overall conclusion was that 7% of the subjects had chronic akathisia and no specific risk factors could be identified.
为确定药物性静坐不能的患病率，对一家医院里66名使用抗精神病药物的智力障碍患者进行了研究。还根据异常不自主运动量表对迟发性运动障碍进行了评分。由于该人群存在语言交流困难，难以引出静坐不能的主观症状，因此仅对静坐不能的运动表现进行评估。由于所有受试者服用抗精神病药物至少已达3年，所以仅能研究慢性静坐不能。有5名受试者出现静坐不能。相关性分析未揭示与所研究的任何人口统计学、临床和药理学变量之间存在任何特定关联。逐步多元回归分析表明，年龄较小可能是一个预测因素。有两名受试者出现迟发性运动障碍。总体结论是，7%的受试者患有慢性静坐不能，且无法确定具体的危险因素。
