Rao J M, Cowie V A, Mathew B
Department of Psychological Medicine, University of Wales, College of Medicine, Cardiff, United Kingdom.
Acta Psychiatr Scand. 1987 Nov;76(5):507-13. doi: 10.1111/j.1600-0447.1987.tb02911.x.
Sixty-seven neuroleptic medicated mentally handicapped subjects in a hospital were rated on two occasions for abnormal involuntary movements on three scales: Abnormal Involuntary Movements (AIMS), Rockland and Parkinsonism scales, with 6 months between each assessment. Inter-rater and test-retest reliabilities were high. The data from the second assessment was analyzed. Prevalence of tardive dyskinesia (TD) was 21% on AIMS, 42% on the Rockland scale; 60% had parkinsonism. Multiple stepwise regression analysis revealed that age, sex, current neuroleptic and anticholinergic dose, antiepileptic medication, psychosis, cumulative anticholinergic dose were not significant predictors of TD as determined by AIMS. Parkinsonism and cumulative neuroleptic dose were significant predictors of and correlated positively with AIMS score. TD subjects formed 35% of the parkinsonian group. Overt brain damage was not a significant predictor of AIMS score and the difference between the neuroleptic medicated and neuroleptic free group on AIMS scores was highly significant.
一家医院的67名使用抗精神病药物治疗的智力障碍患者接受了两次评估，使用三种量表评定异常不自主运动：异常不自主运动量表（AIMS）、罗克兰量表和帕金森症量表，每次评估间隔6个月。评分者间信度和重测信度都很高。对第二次评估的数据进行了分析。AIMS量表上迟发性运动障碍（TD）的患病率为21%，罗克兰量表上为42%；60%有帕金森症。多元逐步回归分析显示，年龄、性别、当前抗精神病药物和抗胆碱能药物剂量、抗癫痫药物、精神病、累积抗胆碱能药物剂量，并非AIMS所确定的TD的显著预测因素。帕金森症和累积抗精神病药物剂量是AIMS评分的显著预测因素，且与AIMS评分呈正相关。TD患者占帕金森症组的35%。明显的脑损伤并非AIMS评分的显著预测因素，使用抗精神病药物组和未使用抗精神病药物组在AIMS评分上的差异非常显著。
