Itescu S, Brancato L J, Winchester R
Hospital for Joint Diseases, New York, NY 10003.
Lancet. 1989 Aug 26;2(8661):466-8. doi: 10.1016/s0140-6736(89)92085-0.
A sicca syndrome with parotid enlargement, pulmonary insufficiency, and lymphadenopathy was seen in 12 patients infected with human immunodeficiency virus (HIV), only 1 of whom has had an opportunistic infection during 304 patient months of study. There was a striking increase in numbers of circulating CD8 lymphocytes and the prevalence of HLA-DR5 was greatly increased. In patients with this diffuse infiltrative lymphocytosis syndrome (DILS) the CD8 lymphocytosis, which probably depends on histocompatibility antigen status, may influence disease progression in HIV infection.
12例感染人类免疫缺陷病毒（HIV）的患者出现了伴有腮腺肿大、肺功能不全和淋巴结病的干燥综合征，在304个患者月的研究期间，其中只有1例发生了机会性感染。循环CD8淋巴细胞数量显著增加，HLA-DR5的患病率也大幅上升。在患有这种弥漫性浸润性淋巴细胞增多综合征（DILS）的患者中，可能取决于组织相容性抗原状态的CD8淋巴细胞增多，可能会影响HIV感染的疾病进展。
