Walker-Bone Karen, Doherty Erin, Sanyal Kaushik, Churchill Duncan
Arthritis Research UK/MRC Centre for Musculoskeletal Health and Work.
Medical Research Council Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton.
Rheumatology (Oxford). 2017 Oct 1;56(10):1648-1661. doi: 10.1093/rheumatology/kew418.
HIV is a global pandemic. However, anti-retroviral therapy has transformed the prognosis and, providing compliance is good, a normal life expectancy can be anticipated. This has led to increasing numbers of people with chronic prevalent, treated infection living to older ages. Musculoskeletal pain is commonly reported by HIV patients and, with resumption of near-normal immune function, HIV-infected patients develop inflammatory rheumatic diseases that require assessment and management in rheumatology clinics. Moreover, it is becoming apparent that avascular necrosis and osteoporosis are common comorbidities of HIV. This review will contextualize the prevalence of musculoskeletal symptoms in HIV, informed by data from a UK-based clinic, and will discuss the management of active inflammatory rheumatic diseases among HIV-infected patients taking anti-retroviral therapy, highlighting known drug interactions.
人类免疫缺陷病毒（HIV）是一种全球性流行病。然而，抗逆转录病毒疗法已经改变了预后，并且如果依从性良好，可以预期正常的预期寿命。这导致越来越多慢性感染且接受治疗的患者活到老年。肌肉骨骼疼痛是HIV患者常见的症状，随着免疫功能恢复接近正常，HIV感染患者会患上炎症性风湿性疾病，需要在风湿病诊所进行评估和管理。此外，越来越明显的是，无血管性坏死和骨质疏松是HIV常见的合并症。本综述将结合一家英国诊所的数据，阐述HIV患者肌肉骨骼症状的患病率，并讨论接受抗逆转录病毒治疗的HIV感染患者中活动性炎症性风湿性疾病的管理，突出已知的药物相互作用。
