Tran Tri Manh, Kannan Kurunthachalam
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, P.O. Box 509, Albany, NY, 12201-0509, USA.
Arch Environ Contam Toxicol. 2015 Apr;68(3):489-99. doi: 10.1007/s00244-015-0140-0. Epub 2015 Feb 22.
Phthalate diesters are used as plasticizers in a wide range of consumer products. Because phthalates have been shown in laboratory animal studies to be toxic, human exposure to these chemicals is a matter of concern. Nevertheless, little is known about inhalation exposure to phthalates in the United States. In this study, occurrence of nine phthalates was determined in 60 indoor air samples collected in 2014 in Albany, New York, USA. Airborne particulate and vapor phase samples were collected from various sampling locations by use of a low-volume air sampler. The median concentrations of nine phthalates in air samples collected from homes, offices, laboratories, schools, salons (hair and nail salons), and public places were 732, 143, 170, 371, 2600, and 354 ng/m(3), respectively. Diethyl phthalate (DEP) was found at the highest concentrations, which ranged from 4.83 to 2250 ng/m(3) (median 152) followed by di-n-butyl phthalate, which ranged from 4.05 to 1170 ng/m(3) (median 63.3). The median inhalation exposure dose to phthalates was estimated at 0.845, 0.423, 0.203, 0.089, and 0.070 µg/kg-bw/d for infants, toddlers, children, teenagers, and adults, respectively. Inhalation is an important pathway of human exposure to DEP.
邻苯二甲酸二酯在众多消费品中用作增塑剂。由于在实验动物研究中已表明邻苯二甲酸盐具有毒性,因此人类接触这些化学物质令人担忧。然而,在美国,人们对通过吸入接触邻苯二甲酸盐的情况知之甚少。在本研究中,测定了2014年在美国纽约州奥尔巴尼采集的60个室内空气样本中9种邻苯二甲酸盐的含量。使用低流量空气采样器从不同采样地点采集空气颗粒物和气相样本。从家庭、办公室、实验室、学校、沙龙(美发和美甲沙龙)及公共场所采集的空气样本中,9种邻苯二甲酸盐的中位浓度分别为732、143、170、371、2600和354 ng/m³。邻苯二甲酸二乙酯(DEP)的浓度最高,范围为4.83至2250 ng/m³(中位值152),其次是邻苯二甲酸二正丁酯,范围为4.05至1170 ng/m³(中位值63.3)。估计婴儿、幼儿、儿童、青少年和成年人通过吸入接触邻苯二甲酸盐的日均剂量分别为0.845、0.423、0.203、0.089和0.070 μg/kg体重。吸入是人类接触DEP的重要途径。